(Q21987826)

serpin family

1 reference

stated in

Serpin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serpin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

21 March 2016

1 reference

21 March 2016

peptidase inhibitor activity

English

molecular function

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

3 references

14 February 2019

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

serine-type endopeptidase inhibitor activity

IPI

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

31 January 2018

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

signaling receptor binding

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

serine-type endopeptidase inhibitor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

2 references

extracellular exosome

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

31 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

collagen-containing extracellular matrix

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

cellular response to transforming growth factor beta stimulus

biological process

1 reference

14 February 2019

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of endothelial cell apoptotic process

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of receptor-mediated endocytosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of peptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of fibrinolysis

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of smooth muscle cell-matrix adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

14 February 2019

Transient reduction of placental angiogenesis in PAI-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

regulation of signaling receptor activity

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of smooth muscle cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of monocyte chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

regulation of angiogenesis

1 reference

14 February 2019

The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of angiogenesis

IDA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Transient reduction of placental angiogenesis in PAI-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

14 February 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of cell migration

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of blood coagulation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

regulation of cell population proliferation

1 reference

14 February 2019

Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of interleukin-8 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

cellular response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of cell adhesion mediated by integrin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of endopeptidase activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22777&geneProductId=UniProtKB:P22777

positive regulation of leukotriene production involved in inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

replicative senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of odontoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

female gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

negative regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of collagen biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of fibroblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of coagulation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of keratinocyte migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

cellular response to interleukin-1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of calcium ion import

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

positive regulation of epithelium regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22777

has part(s)

Serpin, conserved site

1 reference

stated in

Serpin domain

1 reference

stated in

Commons category

Plasminogen activator inhibitor 1

0 references

Identifiers

1 reference

21 March 2016

1 reference

21 March 2016