(Q21990617)

English

Ski oncogene

mouse protein (annotated by UniProtKB/Swiss-Prot Q60698)

Proto-oncogene c-Ski

In more languages

Statements

0 references

SAND-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

Putative DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

Ski-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

SKI/SNO/DAC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

c-SKI SMAD4-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

molecular function

histone deacetylase inhibitor activity

determination method

1 reference

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

zinc ion binding

determination method

2 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

chromatin binding

determination method

1 reference

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

protein binding

determination method

3 references

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

4 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

protein kinase binding

determination method

2 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

2 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

2 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

transcription regulator complex

determination method

1 reference

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

transcription repressor complex

determination method

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Regulation of c-ski transgene expression in developing and mature mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

determination method

2 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

biological process

roof of mouth development

determination method

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

myotube differentiation

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

somatic stem cell population maintenance

determination method

1 reference

14 February 2019

A functional screen to identify novel effectors of hematopoietic stem cell activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

nose morphogenesis

determination method

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

bone morphogenesis

determination method

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Activation of a muscle-specific enhancer by the Ski proto-oncogene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of transforming growth factor beta receptor signaling pathway

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

27 March 2018

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

myelination in peripheral nervous system

determination method

1 reference

14 February 2019

The protooncogene Ski controls Schwann cell proliferation and myelination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

protein homotrimerization

determination method

2 references

negative regulation of BMP signaling pathway

determination method

3 references

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

27 March 2018

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

determination method

neural tube closure

determination method

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

lens morphogenesis in camera-type eye

determination method

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

embryonic limb morphogenesis

determination method

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

skeletal muscle fiber development

determination method

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

retina development in camera-type eye

determination method

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

camera-type eye development

determination method

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

protein heterotrimerization

determination method

1 reference

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

olfactory bulb development

determination method

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

anterior/posterior axis specification

determination method

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of fibroblast proliferation

determination method

1 reference

14 February 2019

Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

face morphogenesis

determination method

camera-type eye morphogenesis

determination method

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Activation of a muscle-specific enhancer by the Ski proto-oncogene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

neuron development

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of histone deacetylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of cell differentiation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of transforming growth factor beta receptor signaling pathway

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

negative regulation of BMP signaling pathway

determination method

4 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

determination method

SKI/SNO/DAC domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

c-SKI SMAD4-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60698

Identifiers

UniProt protein ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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