(Q21990704)

Proteinase inhibitor I35b (TIMP), C-terminal

1 reference

Metalloproteinase inhibitor 2

1 reference

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tissue inhibitor of metalloproteinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

molecular function

peptidase inhibitor activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

enzyme inhibitor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

31 January 2018

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

metalloendopeptidase inhibitor activity

IDA

5 references

31 January 2018

TIMP-2 is required for efficient activation of proMMP-2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

31 January 2018

Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

2 references

metalloendopeptidase inhibitor activity

6 references

14 February 2019

TIMP-2 is required for efficient activation of proMMP-2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

peptidase inhibitor activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

31 January 2018

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

1 reference

31 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

cellular response to organic substance

biological process

1 reference

14 February 2019

Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

regulation of neuron differentiation

IDA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of peptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

regulation of MAPK cascade

1 reference

14 February 2019

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of membrane protein ectodomain proteolysis

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of endopeptidase activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

negative regulation of cell population proliferation

1 reference

31 January 2018

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

positive regulation of catalytic activity

IDA

1 reference

31 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25785&geneProductId=UniProtKB:P25785

negative regulation of metallopeptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

response to organic substance

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

regulation of Rap protein signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

positive regulation of MAPK cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

positive regulation of neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

positive regulation of adenylate cyclase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of proteolysis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of mitotic cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

negative regulation of Ras protein signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25785

1 reference

Tissue inhibitor of metalloproteinase, conserved site

1 reference