(Q21992264)

English

Unc-13 homolog A

mammalian protein found in Mus musculus

Unc13a
protein unc-13 homolog A
Munc13-1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

Protein Unc-13 homologue A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Calcium-dependent secretion activator domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Munc13 homology 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein Unc-13, C2B domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mammalian uncoordinated homology 13, domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

2 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein binding

determination method

4 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein N-terminus binding

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

syntaxin-1 binding

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

phospholipid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

syntaxin-1 binding

determination method

3 references

protein domain specific binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

syntaxin binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

spectrin binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

identical protein binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

neuromuscular junction

determination method

1 reference

16 September 2017

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4KUS2&geneProductId=UniProtKB:Q4KUS2

determination method

plasma membrane

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4KUS2&geneProductId=UniProtKB:Q4KUS2

determination method

determination method

1 reference

8 April 2019

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

determination method

1 reference

8 April 2019

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

neuron projection

determination method

1 reference

16 September 2017

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4KUS2&geneProductId=UniProtKB:Q4KUS2

determination method

terminal bouton

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

determination method

presynaptic active zone

determination method

2 references

synaptic vesicle membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

presynaptic membrane

determination method

4 references

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

presynaptic active zone

determination method

4 references

14 February 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

14 February 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

14 February 2019

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

excitatory synapse

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

synaptic membrane

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

Golgi-associated vesicle

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

presynaptic active zone

determination method

5 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

biological process

chemical synaptic transmission

determination method

2 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

cell differentiation

determination method

2 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

intracellular signal transduction

determination method

2 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

synaptic vesicle docking

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

synaptic transmission, glutamatergic

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

neuromuscular junction development

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

synaptic vesicle maturation

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

determination method

2 references

UniProt protein ID

10 August 2016

language of work or name

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

neurotransmitter secretion

determination method

1 reference

UniProt protein ID

10 August 2016

language of work or name

synaptic vesicle priming

determination method

6 references

8 April 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

synaptic vesicle maturation

determination method

3 references

8 April 2019

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

positive regulation of synaptic plasticity

determination method

1 reference

8 April 2019

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

synaptic transmission, glutamatergic

determination method

4 references

8 April 2019

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

long-term potentiation

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

dense core granule docking

determination method

1 reference

8 April 2019

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

positive regulation of glutamate receptor signaling pathway

determination method

1 reference

8 April 2019

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

regulation of amyloid precursor protein catabolic process

determination method

1 reference

8 April 2019

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4KUS2

determination method

Mammalian uncoordinated homology 13, domain 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

Munc13 homology 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

Calcium-dependent secretion activator domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

Protein Unc-13, C2B domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4KUS2

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000030170

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000030170

ENSMUSP00000135032

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135032

ENSMUSP00000135189

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135189

ENSMUSP00000135528

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135528

ENSMUSP00000135578

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135578

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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