(Q21992409)

Vascular endothelial growth factor, heparin-binding domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Vascular endothelial growth factor, heparin-binding domain, protein family

1 reference

inferred from protein domain or family

PDGF/VEGF domain, protein family

1 reference

inferred from protein domain or family

Platelet-derived growth factor, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

extracellular matrix binding

1 reference

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

signaling receptor binding

1 reference

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

growth factor activity

5 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

vascular endothelial growth factor receptor 2 binding

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

vascular endothelial growth factor receptor 1 binding

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

IPI

chemoattractant activity

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

identical protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

protein heterodimerization activity

1 reference

9 May 2019

Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

vascular endothelial growth factor receptor binding

growth factor activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

growth factor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

protein homodimerization activity

chemoattractant activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 2 binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

The transcription factor Net regulates the angiogenic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

10 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Adenosine receptors in regulation of dendritic cell differentiation and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Adenosine receptors in regulation of dendritic cell differentiation and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of neuron apoptotic process

biological process

1 reference

1 January 2018

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

cardiac vascular smooth muscle cell development

1 reference

1 January 2018

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

outflow tract morphogenesis

1 reference

1 January 2018

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

mammary gland alveolus development

1 reference

9 May 2019

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

9 May 2019

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of retinal ganglion cell axon guidance

1 reference

1 January 2018

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

positive regulation of mesenchymal cell proliferation

1 reference

1 January 2018

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

12 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

VEGFA is necessary for chondrocyte survival during bone development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Aminopeptidase A is a functional target in angiogenic blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

The transcription factor Net regulates the angiogenic switch

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

cell population proliferation

1 reference

9 May 2019

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of p38MAPK cascade

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of neuroblast proliferation

1 reference

9 May 2019

Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

dopaminergic neuron differentiation

IGI

1 reference

9 May 2019

Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of fat cell differentiation

IGI

1 reference

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of protein kinase B signaling

1 reference

1 January 2018

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

9 May 2019

Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

blood vessel morphogenesis

3 references

9 May 2019

Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

NFATc1 regulates lymphatic endothelial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

3 references

1 January 2018

Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

coronary artery morphogenesis

1 reference

1 January 2018

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

negative regulation of extrinsic apoptotic signaling pathway

1 reference

1 January 2018

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

1 January 2018

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

in utero embryonic development

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of lymphangiogenesis

1 reference

9 May 2019

Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

retinal blood vessel morphogenesis

1 reference

14 February 2019

Targeted deletion of Vegfa in adult mice induces vision loss

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of peptidyl-tyrosine phosphorylation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

branching involved in blood vessel morphogenesis

1 reference

1 January 2018

Selective requirements for NRP1 ligands during neurovascular patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

primitive erythrocyte differentiation

1 reference

9 May 2019

SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

epithelial cell differentiation

1 reference

9 May 2019

Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of epithelial cell proliferation

1 reference

9 May 2019

Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of apoptotic process

sprouting angiogenesis

1 reference

1 January 2018

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of angiogenesis

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

regulation of retinal ganglion cell axon guidance

positive regulation of osteoblast differentiation

1 reference

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

lymph vessel morphogenesis

1 reference

1 January 2018

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

post-embryonic camera-type eye development

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

ovarian follicle development

1 reference

9 May 2019

Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

homeostasis of number of cells within a tissue

1 reference

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

lung vasculature development

branching morphogenesis of an epithelial tube

1 reference

1 January 2018

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

coronary vein morphogenesis

1 reference

1 January 2018

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

surfactant homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of endothelial cell proliferation

3 references

1 January 2018

Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

negative regulation of cell-cell adhesion

1 reference

9 May 2019

Abl family kinases regulate endothelial barrier function in vitro and in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of cell migration

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

bone trabecula formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of axon extension involved in axon guidance

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

regulation of endothelial cell differentiation

1 reference

9 May 2019

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

vasculature development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of histone deacetylase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

regulation of hematopoietic progenitor cell differentiation

1 reference

9 May 2019

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

bone trabecula morphogenesis

1 reference

9 May 2019

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

eye photoreceptor cell development

1 reference

9 May 2019

Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

cellular response to vascular endothelial growth factor stimulus

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of cell division

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

endothelial cell migration

1 reference

9 May 2019

Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

camera-type eye morphogenesis

1 reference

9 May 2019

Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 January 2018

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of vascular permeability

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of protein localization to early endosome

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

motor neuron migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of epithelial to mesenchymal transition

1 reference

9 May 2019

Bmp signaling represses Vegfa to promote outflow tract cushion development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

1 January 2018

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00731&geneProductId=UniProtKB:Q00731

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

12 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

VEGFA is necessary for chondrocyte survival during bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Aminopeptidase A is a functional target in angiogenic blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

The transcription factor Net regulates the angiogenic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of protein phosphorylation

positive regulation of endothelial cell proliferation

blood vessel remodeling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

sprouting angiogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

nervous system development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

regulation of nitric oxide mediated signal transduction

1 reference

9 May 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

VEGF-activated neuropilin signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

T-helper 1 type immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of programmed cell death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of angiogenesis

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of bone resorption

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

lung alveolus development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of smooth muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of axon extension involved in axon guidance

1 reference

9 May 2019

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

lung vasculature development

1 reference

9 May 2019

Differential expression of VEGF isoforms in mouse during development and in the adult

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

angiogenesis involved in coronary vascular morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

commissural neuron axon guidance

1 reference

9 May 2019

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

regulation of retinal ganglion cell axon guidance

1 reference

9 May 2019

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

cellular stress response to acid chemical

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

negative regulation of neuron death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of sprouting angiogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

positive regulation of DNA biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

retina blood vessel maintenance

1 reference

9 May 2019

Targeted deletion of Vegfa in adult mice induces vision loss

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00731

1 reference

Platelet-derived growth factor, conserved site

1 reference

Vascular endothelial growth factor, heparin-binding domain

1 reference