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(Q21992476)
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Tyrosine kinase, non-receptor, 1
mammalian protein found in Mus musculus
kinase of embryonic stem cells
non-receptor tyrosine-protein kinase TNK1
Tnk1
non-receptor tyrosine kinase
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99ML2
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase, ATP binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Tyrosine-protein kinase, catalytic domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Tyrosine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99ML2
encoded by
Tnk1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99ML2
molecular function
transferase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
nucleotide binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
protein kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
non-membrane spanning protein tyrosine kinase activity
determination method
IDA
IEA
2 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
27 March 2018
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IDA
kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
protein tyrosine kinase activity
determination method
IEA
ISO
4 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
signaling receptor binding
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IBA
ATP binding
determination method
IEA
IMP
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
ISO
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
non-membrane spanning protein tyrosine kinase activity
determination method
IBA
IDA
IEA
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IBA
cell component
cytoplasm
determination method
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
cytosol
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IDA
membrane
determination method
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
extrinsic component of cytoplasmic side of plasma membrane
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IBA
biological process
cell differentiation
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IBA
phosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
transmembrane receptor protein tyrosine kinase signaling pathway
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IBA
negative regulation of Ras protein signal transduction
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IMP
protein phosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
regulation of cell population proliferation
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IBA
negative regulation of cell growth
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IMP
peptidyl-tyrosine autophosphorylation
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IBA
protein autophosphorylation
determination method
IDA
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IEA
retrieved
14 February 2019
stated in
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
GOA
curator
UniProt
UniProt protein ID
Q99ML2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML2
determination method
IDA
innate immune response
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IBA
cell migration
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML2&geneProductId=UniProtKB:Q99ML2
determination method
IBA
has part(s)
tyrosine-protein kinase, catalytic domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
tyrosine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
serine-threonine/tyrosine-protein kinase, catalytic domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
protein kinase, ATP binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99ML2
Identifiers
RefSeq protein ID
NP_114086
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83813
XP_006534617
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83813
UniProt protein ID
Q99ML2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99ML2
Ensembl protein ID
ENSMUSP00000001626
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000001626
ENSMUSP00000104266
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000104266
ENSMUSP00000104268
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000104268
ENSMUSP00000118490
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000118490
ENSMUSP00000120585
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000120585
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