(Q21992539)

http://www.ebi.ac.uk/interpro/protein/P63147

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Ubiquitin-conjugating enzyme E2 family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

ubiquitin protein ligase activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63147&geneProductId=UniProtKB:P63147

ubiquitin-protein transferase activity

IBA

3 references

3 references

14 February 2019

Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

ubiquitin protein ligase binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

ubiquitin conjugating enzyme activity

IDA

ubiquitin conjugating enzyme activity

IGI

3 references

14 February 2019

Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

1 reference

14 February 2019

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

protein K63-linked ubiquitination

3 references

meiotic telomere clustering

1 reference

14 February 2019

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

positive regulation of reciprocal meiotic recombination

1 reference

14 February 2019

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

negative regulation of apoptotic process

1 reference

14 February 2019

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

in utero embryonic development

1 reference

14 February 2019

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

New insights into the assembly of the periaxonemal structures in mammalian spermatozoa

IGI

sperm axoneme assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

cellular response to DNA damage stimulus

protein K11-linked ubiquitination

ISO

3 references

3 references

histone lysine demethylation

1 reference

14 February 2019

Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

protein K48-linked ubiquitination

3 references

regulation of histone modification

1 reference

14 February 2019

Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

Knockout mouse model and gametogenic failure

protein ubiquitination

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

canonical Wnt signaling pathway

1 reference

27 March 2018

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63147&geneProductId=UniProtKB:P63147

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

synaptonemal complex organization

2 references

14 February 2019

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

positive regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

Rad6B is a positive regulator of beta-catenin stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

protein polyubiquitination

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63147

proteasome-mediated ubiquitin-dependent protein catabolic process

IBA

3 references

Ubiquitin-conjugating enzyme, active site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63147

Ubiquitin-conjugating enzyme E2

1 reference

stated in

InterPro Release 71.0