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(Q21992579)
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WNK lysine deficient protein kinase 2
mammalian protein found in Mus musculus
protein kinase lysine-deficient 2
protein kinase with no lysine 2
serine/threonine-protein kinase WNK2
Wnk2
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q3UH66
part of
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q3UH66
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Serine/threonine-protein kinase OSR1/WNK, CCT domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q3UH66
encoded by
Wnk2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q3UH66
molecular function
transferase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
nucleotide binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
protein kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
ATP binding
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
protein serine/threonine kinase activity
determination method
IEA
IBA
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
chloride channel inhibitor activity
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
potassium channel inhibitor activity
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
cell component
cytoplasm
determination method
IEA
ISO
2 references
retrieved
27 March 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
IEA
plasma membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
cytosol
determination method
IBA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
cytoplasm
determination method
IBA
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
biological process
negative regulation of ERK1 and ERK2 cascade
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
protein autophosphorylation
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
protein phosphorylation
determination method
IDA
IEA
ISO
3 references
retrieved
27 March 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
27 March 2018
stated in
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
IDA
phosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
negative regulation of cell population proliferation
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
positive regulation of sodium ion transmembrane transporter activity
determination method
IBA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
intracellular signal transduction
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
positive regulation of canonical Wnt signaling pathway
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
ion homeostasis
determination method
ISO
1 reference
retrieved
27 March 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UH66&geneProductId=UniProtKB:Q3UH66
determination method
ISO
protein phosphorylation
determination method
IBA
IDA
IEA
ISO
4 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IEA
retrieved
14 February 2019
stated in
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
GOA
curator
UniProt
UniProt protein ID
Q3UH66
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
negative regulation of sodium ion transport
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
positive regulation of ion transmembrane transporter activity
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
ion homeostasis
determination method
IBA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
ISO
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
positive regulation of potassium ion import across plasma membrane
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UH66
determination method
IBA
has part(s)
Serine/threonine-protein kinase OSR1/WNK, CCT domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q3UH66
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q3UH66
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q3UH66
Identifiers
RefSeq protein ID
NP_001277240
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
NP_001277242
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
NP_083637
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_006517037
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_006517040
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_006517042
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242717
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242718
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242719
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242720
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242721
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242722
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242723
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242724
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242725
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242726
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242727
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242728
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_011242729
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_017171115
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_017171116
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103304
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103305
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103306
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103307
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103308
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103309
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_030103310
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014099
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014100
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014101
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014102
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014103
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
XP_036014104
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
75607
UniProt protein ID
Q3UH66
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q3UH66
Ensembl protein ID
ENSMUSP00000047231
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000047231
ENSMUSP00000049327
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000049327
ENSMUSP00000089212
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000089212
ENSMUSP00000105723
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000105723
ENSMUSP00000105724
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000105724
ENSMUSP00000123915
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000123915
ENSMUSP00000124598
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000124598
ENSMUSP00000124614
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000124614
ENSMUSP00000125448
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000125448
ENSMUSP00000125522
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000125522
ENSMUSP00000125539
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000125539
Sitelinks
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Wikiquote
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Multilingual sites
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