(Q21992816)

Zinc finger C2H2 superfamily

1 reference

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Wilm's tumour protein, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

DNA-binding transcription factor activity

1 reference

14 February 2019

Provide fluoxetine information vital to clinicians

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

2 references

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

double-stranded DNA binding

1 reference

14 February 2019

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

hemi-methylated DNA-binding

DNA-binding transcription factor activity, RNA polymerase II-specific

ISS

2 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

4 references

14 February 2019

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

24 April 2018

Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis

IBA

biological process

germ cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

flagellated sperm motility

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

adrenal cortex formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis

male gonad development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

The transcription co-factor CITED2 functions during sex determination and early gonad development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

male genitalia development

IGI

1 reference

14 February 2019

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

epithelial cell differentiation

1 reference

14 February 2019

WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

glomerular visceral epithelial cell development

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

glomerular basement membrane development

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

diaphragm development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

regulation of transcription by RNA polymerase II

1 reference

24 April 2018

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

posterior mesonephric tubule development

1 reference

14 February 2019

Differential regulation of two sets of mesonephric tubules by WT-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

visceral serous pericardium development

3 references

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

Sertoli cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

coronary vasculature development

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

transcription, DNA-templated

TAS

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

negative regulation of mesenchymal cell apoptotic process involved in metanephros development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of metanephric ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

Differential regulation of two sets of mesonephric tubules by WT-1

mesonephros development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of heart growth

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

metanephric comma-shaped body morphogenesis

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

negative regulation of female gonad development

IEP

1 reference

14 February 2019

Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

seminiferous tubule development

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

regulation of animal organ formation

1 reference

14 February 2019

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

cardiac muscle cell fate commitment

1 reference

14 February 2019

De novo cardiomyocytes from within the activated adult heart after injury

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

24 April 2018

A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

regulation of gene expression

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

glomerular visceral epithelial cell differentiation

1 reference

24 April 2018

Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

camera-type eye development

1 reference

14 February 2019

The Wilms' tumor gene Wt1 is required for normal development of the retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

metanephric S-shaped body morphogenesis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

IEP

metanephros development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

thorax and anterior abdomen determination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

negative regulation of transcription, DNA-templated

4 references

14 February 2019

The Wilms' tumor suppressor gene WT1 is negatively autoregulated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Provide fluoxetine information vital to clinicians

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

metanephric mesenchyme development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of male gonad development

1 reference

14 February 2019

Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

negative regulation of cell population proliferation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

negative regulation of metanephric glomerular mesangial cell proliferation

1 reference

14 February 2019

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

1 reference

14 February 2019

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of transcription, DNA-templated

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Provide fluoxetine information vital to clinicians

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22561&geneProductId=UniProtKB:P22561

negative regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

cellular response to cAMP

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

cellular response to gonadotropin stimulus

IBA

3 references

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

positive regulation of DNA methylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22561

has part(s)

Zinc finger C2H2-type

1 reference

Wilm's tumour protein, N-terminal

1 reference