(Q22677568)

GPCR, family 2, corticotropin releasing factor receptor, type 1

1 reference

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.4.3

2 October 2019

hierarchical database ID heuristic

membrane protein

1 reference

inferred from GOA cell component → membrane

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

16 March 2017

signal transducer activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34998&geneProductId=UniProtKB:P34998

3 references

8 April 2019

Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

8 April 2019

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

corticotrophin-releasing factor receptor activity

IPI

2 references

16 July 2018

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34998&geneProductId=UniProtKB:P34998

16 July 2018

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34998&geneProductId=UniProtKB:P34998

transmembrane signaling receptor activity

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

corticotrophin-releasing factor receptor activity

3 references

8 April 2019

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

8 April 2019

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

peptide hormone binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

corticotropin-releasing hormone receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

corticotropin-releasing hormone binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

G-protein alpha-subunit binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

corticotrophin-releasing factor receptor activity

4 references

1 January 2018

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 January 2018

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

protein-containing complex binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

2 references

intrinsic component of plasma membrane

1 reference

8 April 2019

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

integral component of plasma membrane

1 reference

8 April 2019

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

biological process

corticotropin secretion

1 reference

8 April 2019

1 reference

8 April 2019

A placental clock controlling the length of human pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

activation of adenylate cyclase activity

NAS

1 reference

8 April 2019

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway

TAS

1 reference

8 April 2019

Structure of class B GPCR corticotropin-releasing factor receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

cell surface receptor signaling pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

8 April 2019

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

8 April 2019

Expression cloning of a human corticotropin-releasing-factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

cellular response to corticotropin-releasing hormone stimulus

TAS

1 reference

8 April 2019

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

regulation of corticosterone secretion

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

negative regulation of voltage-gated calcium channel activity

ISS

1 reference

8 April 2019

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

hormone-mediated signaling pathway

IDA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

positive regulation of cytosolic calcium ion concentration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

neuropeptide signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

hypothalamus development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

adrenal gland development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

epithelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

negative regulation of epinephrine secretion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

locomotory exploration behavior

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

response to immobilization stress

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

positive regulation of mast cell degranulation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

positive regulation of cAMP-mediated signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

behavioral response to cocaine

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

behavioral response to ethanol

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

regulation of synaptic plasticity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

behavioral response to pain

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

response to electrical stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

general adaptation syndrome, behavioral process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

long-term potentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

negative regulation of neuron death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

negative regulation of feeding behavior

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34998

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

3489

English

GPCR, family 2, extracellular hormone receptor domain

27 April 2016

has part(s)

1 reference

GPCR, family 2, secretin-like, conserved site

1 reference

GPCR, family 2-like

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.4.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database