(Q22678778)

http://www.ebi.ac.uk/interpro/protein/P97718

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

adrenergic receptor activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

alpha1-adrenergic receptor activity

5 references

16 July 2018

Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

protein heterodimerization activity

alpha1-adrenergic receptor activity

6 references

8 April 2019

Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

glutamatergic synapse

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

integral component of postsynaptic membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

integral component of presynaptic membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

regulation of muscle contraction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

8 April 2019

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

1 reference

16 July 2018

Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

IMP

adult heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

positive regulation of heart rate by epinephrine-norepinephrine

1 reference

8 April 2019

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

16 July 2018

Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

8 April 2019

The basement membrane of hair follicle stem cells is a muscle cell niche

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of the force of heart contraction by epinephrine-norepinephrine

1 reference

8 April 2019

Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

1 reference

8 April 2019

Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

regulation of cardiac muscle contraction

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of MAPK cascade

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

negative regulation of autophagy

1 reference

8 April 2019

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of non-membrane spanning protein tyrosine kinase activity

1 reference

8 April 2019

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

cell growth involved in cardiac muscle cell development

1 reference

8 April 2019

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of cytosolic calcium ion concentration

positive regulation of vasoconstriction

positive regulation of smooth muscle contraction

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

16 July 2018

The basement membrane of hair follicle stem cells is a muscle cell niche

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

regulation of synaptic vesicle exocytosis

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97718&geneProductId=UniProtKB:P97718

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

IMP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

positive regulation of smooth muscle contraction

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

The basement membrane of hair follicle stem cells is a muscle cell niche

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

neuron-glial cell signaling

1 reference

8 April 2019

Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+) release in Bergmann glial cells in situ.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97718

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0