(Q2308016)

P-loop containing nucleoside triphosphate hydrolase

1 reference

Transporter Classification Database ID

Membrane contact site

1 reference

1.R.1.1.1

retrieved

2 October 2019

hierarchical database ID heuristic

ATPase, AAA-type, core domain, protein family

1 reference

MIT domain, protein family

1 reference

AAA proteins

1 reference

Vps4 oligomerisation, C-terminal domain, protein family

1 reference

ATPase, AAA-type, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

alpha-tubulin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

microtubule-severing ATPase activity

IPI

7 references

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Graded Control of Microtubule Severing by Tubulin Glutamylation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 references

8 April 2019

SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

2 references

4 references

7 March 2017

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

microtubule-severing ATPase activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Graded Control of Microtubule Severing by Tubulin Glutamylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

protein-containing complex binding

IBA

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

microtubule cytoskeleton

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

microtubule organizing center

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

4 references

8 April 2019

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

8 April 2019

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

4 references

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

3 references

7 March 2017

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

endoplasmic reticulum membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

endoplasmic reticulum tubular network

1 reference

7 March 2017

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

positive regulation of cytokinesis

1 reference

8 April 2019

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

microtubule bundle formation

1 reference

8 April 2019

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

protein homooligomerization

1 reference

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

nuclear membrane reassembly

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

cytoplasmic microtubule organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

7 references

7 March 2017

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Graded Control of Microtubule Severing by Tubulin Glutamylation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

7 March 2017

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

mitotic spindle disassembly

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

1 reference

8 April 2019

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

endoplasmic reticulum to Golgi vesicle-mediated transport

1 reference

7 March 2017

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

protein hexamerization

1 reference

7 March 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

7 March 2017

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

positive regulation of microtubule depolymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

9 references

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Graded Control of Microtubule Severing by Tubulin Glutamylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

Human spastin has multiple microtubule-related functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

8 April 2019

The nucleotide cycle of spastin correlates with its microtubule-binding properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

cytoskeleton-dependent cytokinesis

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0

TAS

Gene Atlas image

PBB GE SPAST 207724 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

MIT

1 reference

ATPase, AAA-type, conserved site

1 reference

Vps4 oligomerisation, C-terminal

1 reference

AAA+ ATPase domain

1 reference

ATPase, AAA-type, core

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

8 February 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

1.R.1.1.1

2 references

Transporter Classification database

retrieved

13 March 2020