(Q28370964)

English

CCND1 Overexpression

genetic variant

OVEREXPRESSION

In more languages

Statements

sequence variant

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

human chromosome 11

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

69455855

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

69469242

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

positive therapeutic predictor for

medical condition treated

mantle cell lymphoma

statement disputed by

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

determination method

CIViC evidence level B

CIViC 2-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1536

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

medical condition treated

mantle cell lymphoma

determination method

CIViC evidence level D

CIViC 1-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1563

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.

negative therapeutic predictor for

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

estrogen-receptor positive breast cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/856

Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

positive diagnostic predictor for

determination method

CIViC evidence level B

CIViC 4-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/221

Cyclin D1 in breast cancer pathogenesis

negative prognostic predictor for

mantle cell lymphoma

determination method

CIViC evidence level B

CIViC 4-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/358

Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

head and neck squamous cell carcinoma

determination method

CIViC evidence level B

CIViC 4-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/357

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

determination method

CIViC evidence level B

CIViC 4-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/356

Cyclin D1 in breast cancer pathogenesis

B-cell childhood acute lymphoblastic leukemia

determination method

CIViC evidence level B

CIViC 2-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/8115

Ribociclib, A Cdk4/Cdk6 Kinase Inhibitor, Enhances Glucocorticoid Sensitivity In B-Acute Lymphoblastic Leukemia (B-All).

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

HGVS nomenclature

no value

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/20

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