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(Q28370977)
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ERBB2 L755S
genetic variant
L755S
LEU755SER
L725S
L740S
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Statements
instance of
missense mutation
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
chromosome
human chromosome 17
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
genomic start
37880220
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
genomic end
37880220
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
biological variant of
ERBB2
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
positive therapeutic predictor for
lapatinib / neratinib / Trastuzumab combination therapy
medical condition treated
colon cancer
determination method
CIViC evidence level D
rating
CIViC 4-star trust rating
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/1176
stated in
HER2 activating mutations are targets for colorectal cancer treatment
neratinib
medical condition treated
breast cancer
determination method
CIViC evidence level D
rating
CIViC 5-star trust rating
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/283
stated in
Activating HER2 mutations in HER2 gene amplification negative breast cancer
negative therapeutic predictor for
lapatinib
determination method
CIViC evidence level D
rating
CIViC 5-star trust rating
medical condition treated
breast cancer
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/241
stated in
Activating HER2 mutations in HER2 gene amplification negative breast cancer
Identifiers
CIViC variant ID
39
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
dbSNP Reference SNP number
rs121913470
1 reference
stated in
CIViC database
HGVS nomenclature
NC_000017.10:g.37880220T>C
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
ENST00000269571.5:c.2264T>C
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
NM_004448.3:c.2264T>C
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
NP_004439.2:p.Leu755Ser
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/39
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