(Q28371012)

English

KRAS G12D

genetic variant

GLY12ASP
G12D
RS121913529

In more languages

Statements

missense mutation

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

human chromosome 12

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

25398284

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

25398284

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

positive therapeutic predictor for

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

pancreatic carcinoma

1 reference

23 September 2019

https://civic.genome.wustl.edu/links/evidence/937

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

negative therapeutic predictor for

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

hairy cell leukemia

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1580

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia

determination method

CIViC evidence level B

CIViC 2-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/2240

PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients.

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6316

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6316

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

determination method

CIViC evidence level B

CIViC 2-star trust rating

medical condition treated

multiple myeloma

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/2247

Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/3957

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/3958

Cetuximab inhibits the growth of mucinous ovarian carcinoma tumor cells lacking KRAS gene mutations

determination method

CIViC evidence level D

CIViC 1-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/3946

KRAS exon 2 mutations influence activity of regorafenib in an SW48-based disease model of colorectal cancer

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/2193

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/2207

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

positive diagnostic predictor for

determination method

CIViC evidence level B

CIViC 3-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/228

Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers

positive prognostic predictor for

colorectal cancer

determination method

CIViC evidence level B

CIViC 3-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1215

Impact of the specific mutation in KRAS codon 12 mutated tumors on treatment efficacy in patients with metastatic colorectal cancer receiving cetuximab-based first-line therapy: a pooled analysis of three trials.

negative prognostic predictor for

cancer of exocrine pancreas

determination method

CIViC evidence level B

CIViC 3-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1311

Somatic mutations in exocrine pancreatic tumors: association with patient survival

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

dbSNP Reference SNP number

1 reference

HGVS nomenclature

NM_004985.4:c.35G>A

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

NP_004976.2:p.Gly12Asp

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

NC_000012.11:g.25398284C>T

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

ENST00000256078.4:c.35G>A

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/79

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