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PIK3CA Exon 21 Mutation
genetic variant
EXON 21 MUTATION
EXON 20 MUTATION
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Statements
instance of
exon variant
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
chromosome
human chromosome 3
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
genomic start
178951882
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
genomic end
178952495
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
biological variant of
PIK3CA
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
negative therapeutic predictor for
cetuximab / chemotherapy combination therapy
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
medical condition treated
colorectal cancer
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/138
stated in
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
positive prognostic predictor for
breast cancer
determination method
CIViC evidence level B
rating
CIViC 4-star trust rating
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/6198
stated in
Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas
negative prognostic predictor for
colorectal cancer
determination method
CIViC evidence level B
rating
CIViC 2-star trust rating
statement disputed by
Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/3729
stated in
Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review
Identifiers
CIViC variant ID
105
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/105
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