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TP53 R273C
genetic variant
ARG273CYS
R273C
R141C
R234C
RS121913343
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Statements
instance of
missense mutation
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
chromosome
human chromosome 17
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
genomic start
7577121
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
genomic end
7577121
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
biological variant of
TP53
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
positive therapeutic predictor for
etoposide / mitomycin / cisplatin combination therapy
determination method
CIViC evidence level C
rating
CIViC 3-star trust rating
statement disputed by
Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer
medical condition treated
stomach carcinoma
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/2292
stated in
Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer
negative prognostic predictor for
breast cancer
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
2 references
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/395
stated in
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/396
stated in
Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer
Identifiers
CIViC variant ID
121
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
dbSNP Reference SNP number
rs121913343
1 reference
stated in
CIViC database
HGVS nomenclature
NM_000546.5:c.817C>T
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
NP_000537.3:p.Arg273Cys
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
NC_000017.10:g.7577121G>A
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
ENST00000269305.4:c.817C>T
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/121
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