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TP53 R273H
genetic variant
ARG273HIS
R273H
R141H
R234H
RS28934576
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No description defined
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Statements
instance of
missense mutation
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
chromosome
human chromosome 17
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
genomic start
7577120
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
genomic end
7577120
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
biological variant of
TP53
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
negative therapeutic predictor for
methotrexate
determination method
CIViC evidence level D
rating
CIViC 3-star trust rating
medical condition treated
osteosarcoma
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7430
stated in
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3
doxorubicin
determination method
CIViC evidence level D
rating
CIViC 3-star trust rating
medical condition treated
osteosarcoma
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7430
stated in
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3
negative prognostic predictor for
breast cancer
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
2 references
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/397
stated in
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/398
stated in
Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer
Identifiers
CIViC variant ID
122
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
dbSNP Reference SNP number
rs28934576
1 reference
stated in
CIViC database
HGVS nomenclature
NM_000546.5:c.818G>A
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
NP_000537.3:p.Arg273His
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
NC_000017.10:g.7577120C>T
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
ENST00000269305.4:c.818G>A
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/122
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