(Q28371565)

English

BRAF D594G

genetic variant

ASP594GLY
D594G
RS121913338

In more languages

Statements

missense mutation

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

human chromosome 7

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

140453154

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

140453154

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

positive therapeutic predictor for

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6001

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/7760

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

statement disputed by

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/7556

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

negative therapeutic predictor for

medical condition treated

colorectal cancer

statement disputed by

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

determination method

CIViC evidence level C

CIViC 1-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1554

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

medical condition treated

colorectal cancer

statement disputed by

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

determination method

CIViC evidence level C

CIViC 1-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1554

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

irinotecan / Cetuximab combination therapy

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

colorectal cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/4472

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients

irinotecan / Cetuximab combination therapy

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

colorectal cancer

statement disputed by

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/2201

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

negative prognostic predictor for

colorectal cancer

determination method

CIViC evidence level B

CIViC 1-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1551

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

colorectal cancer

determination method

CIViC evidence level B

CIViC 2-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1553

Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

dbSNP Reference SNP number

1 reference

HGVS nomenclature

NM_004333.4:c.1781A>G

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

NP_004324.2:p.Asp594Gly

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

NC_000007.13:g.140453154T>C

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

ENST00000288602.6:c.1781A>G

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/611

Sitelinks

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Wiktionary(0 entries)

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