(Q28444960)

English

BRCA1 Mutation

genetic variant

MUTATION

In more languages

Statements

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

Loss Of Function Variant

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

human chromosome 17

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

41197646

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

41277500

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

positive therapeutic predictor for

determination method

CIViC evidence level A

CIViC 4-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1370

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

cediranib / olaparib combination therapy

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1677

Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

triple-negative breast cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1684

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1772

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

determination method

CIViC evidence level B

CIViC 4-star trust rating

medical condition treated

pancreatic cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/5915

Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers

determination method

CIViC evidence level B

CIViC 4-star trust rating

medical condition treated

pancreatic cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/5915

Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6341

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

pancreatic cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/5914

Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

triple-negative breast cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1684

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

negative therapeutic predictor for

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

triple-negative breast cancer

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1775

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

positive prognostic predictor for

surface epithelial-stromal tumor

determination method

CIViC evidence level B

CIViC 3-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/464

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

determination method

CIViC evidence level B

CIViC 3-star trust rating

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1675

BRCA1/2 mutations associated with progression-free survival in ovarian cancer patients in the AGO-OVAR 16 study.

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/185

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