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PIK3CA Amplification
genetic variant
AMPLIFICATION
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Statements
instance of
Transcript Amplification
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
chromosome
human chromosome 3
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
genomic start
178866311
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
genomic end
178957881
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
biological variant of
PIK3CA
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
positive therapeutic predictor for
pictilisib
determination method
CIViC evidence level C
rating
CIViC 2-star trust rating
medical condition treated
surface epithelial-stromal tumor
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/756
stated in
First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors
negative therapeutic predictor for
vemurafenib
determination method
CIViC evidence level D
rating
CIViC 2-star trust rating
medical condition treated
melanoma
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/6275
stated in
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
trastuzumab
determination method
CIViC evidence level D
rating
CIViC 2-star trust rating
medical condition treated
Her2-receptor positive breast cancer
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/8267
stated in
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.
negative prognostic predictor for
gastric adenocarcinoma
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/504
stated in
Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
Identifiers
CIViC variant ID
212
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
HGVS nomenclature
no value
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/212
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