(Q28557592)

EF-hand domain pair

1 reference

C2 domain superfamily

1 reference

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

PH-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

EF-hand domain, protein family

1 reference

pleckstrin homology domain, protein family

1 reference

C2 domain, protein family

1 reference

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

Phosphoinositide-specific phospholipase C, EF-hand-like domain, protein family

1 reference

EF-Hand 1, calcium-binding site, protein family

1 reference

phosphatidylinositol phospholipase C activity

1 reference

17 November 2021

1 reference

17 November 2021

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

3 references

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

Catalysis by phospholipase C delta1 requires that Ca2+ bind to the catalytic domain, but not the C2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

3 references

14 February 2019

Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

calcium-dependent phospholipid binding

IDA

1 reference

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

phosphoric diester hydrolase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

inositol 1,4,5 trisphosphate binding

IEA

1 reference

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake

IDA

mitochondrial membranes

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

14 February 2019

Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

2 references

2 references

G protein-coupled receptor signaling pathway

1 reference

14 February 2019

Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains

IDA

response to aluminum ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

response to organonitrogen compound

1 reference

14 February 2019

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

positive regulation of norepinephrine secretion

1 reference

14 February 2019

Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

lipid catabolic process

1 reference

14 February 2019

positive regulation of inositol trisphosphate biosynthetic process

IEA

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

response to prostaglandin F

1 reference

14 February 2019

Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

intracellular signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

response to peptide hormone

IEA

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Novel regulation of PLCζ activity via its XY-linker

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation

response to calcium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

response to hyperoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

regulation of phospholipase C activity

1 reference

14 February 2019

Novel regulation of PLCζ activity via its XY-linker

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

inositol trisphosphate biosynthetic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

1 reference

C2 domain

1 reference

EF-hand 1, calcium-binding site

1 reference

pleckstrin homology domain

1 reference

Phosphoinositide-specific phospholipase C, EF-hand-like domain

1 reference

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference