(Q28557794)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08909

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

Gq/11-coupled serotonin receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

G protein-coupled serotonin receptor activity

Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

14 February 2019

14 February 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

protein binding

IPI

1 reference

14 February 2019

Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

neurotransmitter receptor activity

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

cell component

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

external side of plasma membrane

1 reference

14 February 2019

The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

cell surface

1 reference

14 February 2019

Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

dendrite

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

biological process

behavioral fear response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

TAS

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

phospholipase C-activating serotonin receptor signaling pathway

1 reference

14 February 2019

Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

chemical synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

animal behaviour

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

locomotory behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

positive regulation of gamma-aminobutyric acid secretion

1 reference

14 February 2019

In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

positive regulation of acetylcholine secretion, neurotransmission

1 reference

14 February 2019

Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

animal organ regeneration

IEP

1 reference

14 February 2019

Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

phospholipase D-activating G protein-coupled receptor signaling pathway

IEP

1 reference

14 February 2019

Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

regulation of nervous system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

regulation of appetite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

behavioral response to nicotine

1 reference

14 February 2019

The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

negative regulation of locomotion

1 reference

14 February 2019

Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

regulation of corticotropin-releasing hormone secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

positive regulation of vasoconstriction

1 reference

14 February 2019

Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

negative regulation of dopamine metabolic process

1 reference

14 February 2019

Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

inositol phosphate-mediated signaling

1 reference

14 February 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

1 reference

14 February 2019

regulation of sensory perception of pain

1 reference

14 February 2019

Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08909

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

InterPro Release 71.0