(Q28557945)

English

Arrestin, beta 2

mammalian protein found in Rattus norvegicus

beta-arrestin-2
Arrb2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Arrestin, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Arrestin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Arrestin C-terminal-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Arrestin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Arrestin-like, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

G protein-coupled receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein binding

determination method

5 references

9 May 2019

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

A beta-arrestin 2 signaling complex mediates lithium action on behavior

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein domain specific binding

determination method

1 reference

9 May 2019

Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

ubiquitin protein ligase binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

alpha-1A adrenergic receptor binding

determination method

1 reference

9 May 2019

Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

alpha-1B adrenergic receptor binding

determination method

1 reference

9 May 2019

Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

angiotensin receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

type 1 angiotensin receptor binding

determination method

1 reference

9 May 2019

Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

D1 dopamine receptor binding

determination method

1 reference

9 May 2019

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

follicle-stimulating hormone receptor binding

determination method

1 reference

9 May 2019

G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

type 2A serotonin receptor binding

determination method

1 reference

9 May 2019

Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

platelet activating factor receptor binding

determination method

1 reference

9 May 2019

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

identical protein binding

determination method

1 reference

9 May 2019

beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein kinase B binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

mitogen-activated protein kinase binding

determination method

1 reference

9 May 2019

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

14-3-3 protein binding

determination method

1 reference

9 May 2019

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

arrestin family protein binding

determination method

1 reference

9 May 2019

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

8 April 2019

G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

1 reference

9 May 2019

Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

clathrin-coated pit

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

postsynaptic density

determination method

1 reference

9 May 2019

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

basolateral plasma membrane

determination method

1 reference

9 May 2019

G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

dendritic spine

determination method

1 reference

9 May 2019

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

intracellular membrane-bounded organelle

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

biological process

regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

G protein-coupled receptor internalization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

determination method

1 reference

9 May 2019

A G protein-coupled receptor kinase induces Xenopus oocyte maturation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

9 May 2019

Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

brain development

determination method

1 reference

9 May 2019

Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

adult walking behavior

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of signal transduction

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

protein ubiquitination

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of protein ubiquitination

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

receptor internalization

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of synaptic transmission, dopaminergic

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of interleukin-1 beta production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of interleukin-12 production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of interleukin-6 production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of collagen biosynthetic process

determination method

1 reference

9 May 2019

β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

9 May 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of toll-like receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of GTPase activity

determination method

1 reference

9 May 2019

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of smooth muscle cell apoptotic process

determination method

1 reference

9 May 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

follicle-stimulating hormone signaling pathway

determination method

1 reference

9 May 2019

G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

9 May 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of neuron apoptotic process

determination method

1 reference

9 May 2019

Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of natural killer cell mediated cytotoxicity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

detection of temperature stimulus involved in sensory perception of pain

determination method

1 reference

9 May 2019

Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of calcium ion transport

determination method

1 reference

9 May 2019

{Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

cell chemotaxis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

regulation of androgen receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

4 references

8 April 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

8 April 2019

β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

8 April 2019

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

negative regulation of release of cytochrome c from mitochondria

determination method

1 reference

9 May 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of epithelial cell apoptotic process

determination method

1 reference

9 May 2019

Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of DNA biosynthetic process

determination method

1 reference

9 May 2019

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of cardiac muscle cell differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

5 references

9 May 2019

β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29067

determination method

Arrestin-like, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Arrestin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Arrestin C-terminal-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29067

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000026207

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000026207

ENSRNOP00000095625

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000095625

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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