(Q28558126)

http://www.ebi.ac.uk/interpro/protein/Q63768

SH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63768

membrane protein

1 reference

inferred from GOA cell component → membrane

SH2 domain, protein family

1 reference

CRK, N-terminal SH3 domain, protein family

1 reference

CRK, C-terminal SH3 domain, protein family

1 reference

SH3 domain, protein family

1 reference

phosphotyrosine residue binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

insulin-like growth factor receptor binding

1 reference

14 February 2019

TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

6 references

14 February 2019

Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

14 February 2019

Abl silencing inhibits CAS-mediated process and constriction in resistance arteries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

14 February 2019

Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

14 February 2019

Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

14 February 2019

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

14 February 2019

Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cytoskeletal protein binding

1 reference

14 February 2019

Abl silencing inhibits CAS-mediated process and constriction in resistance arteries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

protein domain specific binding

1 reference

14 February 2019

Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

protein-macromolecule adaptor activity

1 reference

14 February 2019

CrkII signals from epidermal growth factor receptor to Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

protein self-association

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

protein phosphorylated amino acid binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

ephrin receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration

scaffold protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of leukocyte migration

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of cell shape

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

positive regulation of smooth muscle cell migration

1 reference

14 February 2019

Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cerebral cortex development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

establishment of cell polarity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of cell adhesion mediated by integrin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of Rac protein signal transduction

1 reference

14 February 2019

Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

IMP

helper T cell diapedesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

response to hepatocyte growth factor

1 reference

14 February 2019

Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

reelin-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

response to hydrogen peroxide

1 reference

14 February 2019

Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

negative regulation of natural killer cell mediated cytotoxicity

1 reference

14 February 2019

Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of dendrite development

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

negative regulation of wound healing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

response to cholecystokinin

1 reference

14 February 2019

Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cellular response to transforming growth factor beta stimulus

IDA

1 reference

14 February 2019

TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cellular response to nitric oxide

1 reference

14 February 2019

Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

activation of GTPase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cerebellar neuron development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

1 reference

14 February 2019

Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cellular response to nerve growth factor stimulus

1 reference

14 February 2019

Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cellular response to insulin-like growth factor stimulus

IDA

1 reference

14 February 2019

TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

cellular response to endothelin

1 reference

14 February 2019

Selective Involvement of p130Cas/Crk/Pyk2/c-Src in Endothelin-1-Induced JNK Activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

negative regulation of cell motility

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768

regulation of T cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768