(Q28558146)

http://www.ebi.ac.uk/interpro/protein/P06762

Haem oxygenase-like, multi-helical

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06762

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Haem oxygenase conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

heme oxygenase (decyclizing) activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Cloning and expression of cDNA for rat heme oxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats

phospholipase D activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Caveolae compartmentalization of heme oxygenase-1 in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

IPI

oxidoreductase activity

1 reference

14 February 2019

1 reference

14 February 2019

Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

endoplasmic reticulum

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Caveolae compartmentalization of heme oxygenase-1 in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Cloning and expression of cDNA for rat heme oxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Caveolae compartmentalization of heme oxygenase-1 in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

wound healing involved in inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

phospholipid metabolic process

1 reference

14 February 2019

Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular iron ion homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

response to oxidative stress

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

small GTPase mediated signal transduction

1 reference

14 February 2019

Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

regulation of blood pressure

1 reference

14 February 2019

Selective regulation of blood pressure by heme oxygenase-1 in hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of cell population proliferation

1 reference

14 February 2019

Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

14 February 2019

Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of muscle cell apoptotic process

1 reference

14 February 2019

Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

positive regulation of macroautophagy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of macroautophagy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to nutrient

1 reference

14 February 2019

Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of mast cell cytokine production

IEP

1 reference

14 February 2019

Heme oxygenase-1 inhibits cytokine production by activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

erythrocyte homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

regulation of transcription from RNA polymerase II promoter in response to iron

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to heat

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

intracellular signal transduction

1 reference

14 February 2019

Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

heme catabolic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Caveolae compartmentalization of heme oxygenase-1 in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

heme metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

response to hydrogen peroxide

1 reference

14 February 2019

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

positive regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of mast cell degranulation

1 reference

14 February 2019

Heme oxygenase-1 inhibits cytokine production by activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of DNA binding

1 reference

14 February 2019

Heme oxygenase-1 inhibits cytokine production by activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Heme oxygenase-1 inhibits cytokine production by activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

1 reference

14 February 2019

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

protein homooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to arsenic-containing substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

cellular response to cisplatin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

positive regulation of cell migration involved in sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

1 reference

14 February 2019

Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of epithelial cell apoptotic process

1 reference

14 February 2019

The role of heme oxygenase 1 in hydrogen peroxide induced apoptosis and mitochondrial trans membrane potential change in rat primary type II alveolar epithelium cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

14 February 2019

Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762

Haem oxygenase conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0