(Q28558474)

Mir domain superfamily

1 reference

inositol 1,4,5-trisphosphate receptors

1 reference

Armadillo-type fold

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain, protein family

1 reference

Ion transport domain, protein family

1 reference

MIR motif domain, protein family

1 reference

RyR/IP3R Homology associated domain, protein family

1 reference

RIH domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IBA

calcium channel activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

7 references

14 February 2019

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

protein C-terminus binding

IPI

1 reference

14 February 2019

Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

calcium-release channel activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

protein phosphatase binding

ISS

1 reference

14 February 2019

Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

protein-containing complex binding

1 reference

14 February 2019

Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

endoplasmic reticulum

endoplasmic reticulum membrane

2 references

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

2 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

integral component of endoplasmic reticulum membrane

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

transport vesicle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

cytoplasmic vesicle membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

smooth endoplasmic reticulum membrane

IBA

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

integral component of organelle membrane

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

protein-containing complex

1 reference

14 February 2019

Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

intracellular membrane-bounded organelle

1 reference

14 February 2019

Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

2 references

calcium ion transport

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

positive regulation of cytosolic calcium ion concentration

positive regulation of neuron projection development

1 reference

14 February 2019

Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

positive regulation of apoptotic process

IEP

1 reference

14 February 2019

Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

inositol phosphate-mediated signaling

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

protein homotetramerization

1 reference

14 February 2019

Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

positive regulation of calcium ion transport

1 reference

14 February 2019

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

transmembrane transport

1 reference

14 February 2019

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

calcium ion transmembrane transport

ISS

cellular response to cAMP

2 references

1 reference

14 February 2019

Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

cellular response to hypoxia

1 reference

14 February 2019

Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

14 February 2019

Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

negative regulation of neuron death

1 reference

14 February 2019

Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

positive regulation of hepatocyte proliferation

1 reference

14 February 2019

Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994

1 reference

RIH domain

1 reference

RyR/IP3R Homology associated domain

1 reference

MIR motif

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain

1 reference