(Q28560282)

English

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

mammalian protein found in Rattus norvegicus

SR Ca(2+)-ATPase 2
endoplasmic reticulum class 1/2 Ca(2+) ATPase
ATPase, Ca++ transporting, slow twitch 2
calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
calcium pump 2
Atp2a2
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

2 references

P-type calcium transporter activity

determination method

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

protein binding

determination method

1 reference

14 February 2019

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

determination method

3 references

P-type proton-exporting transporter activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

hydrolase activity

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11507&geneProductId=UniProtKB:P11507

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

lutropin-choriogonadotropic hormone receptor binding

determination method

1 reference

14 February 2019

The endoplasmic reticulum Ca2+-pump SERCA2b interacts with G protein-coupled receptors and enhances their expression at the cell surface

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

S100 protein binding

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

endoplasmic reticulum

determination method

3 references

vesicle membrane

determination method

1 reference

14 February 2019

Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

determination method

2 references

integral component of membrane

determination method

2 references

sarcoplasmic reticulum

determination method

6 references

14 February 2019

Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Molecular cloning and quantification of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat muscles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

14 February 2019

Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

protein-containing complex

determination method

1 reference

14 February 2019

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

sarcoplasmic reticulum membrane

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

perinuclear region of cytoplasm

determination method

1 reference

14 February 2019

Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

apical ectoplasmic specialization

determination method

1 reference

14 February 2019

Ca2+ signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cells.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

plasma membrane bounded cell projection

determination method

1 reference

14 February 2019

Ca2+ signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cells.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

biological process

regulation of the force of heart contraction

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

skeletal muscle contraction

determination method

1 reference

14 February 2019

Variation in expression of calcium-handling proteins is associated with inter-individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

calcium ion transport

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

regulation of muscle contraction

determination method

1 reference

14 February 2019

Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

ER-nucleus signaling pathway

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

organelle organization

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

regulation of cardiac muscle contraction by calcium ion signaling

determination method

transition between fast and slow fiber

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

cardiac muscle hypertrophy in response to stress

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

endoplasmic reticulum calcium ion homeostasis

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

positive regulation of endoplasmic reticulum calcium ion concentration

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

response to lipopolysaccharide

determination method

1 reference

14 February 2019

TNF-α down-regulates sarcoplasmic reticulum Ca²⁺ ATPase expression and leads to left ventricular diastolic dysfunction through binding of NF-κB to promoter response element

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

T-tubule organization

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

cellular response to oxidative stress

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

cellular response to heat

determination method

1 reference

14 February 2019

The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

negative regulation of heart contraction

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

relaxation of cardiac muscle

determination method

1 reference

14 February 2019

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

calcium ion transmembrane transport

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

regulation of cardiac muscle cell membrane potential

determination method

1 reference

14 February 2019

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

regulation of cardiac muscle cell action potential involved in regulation of contraction

determination method

1 reference

14 February 2019

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

proton transmembrane transport

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

regulation of calcium ion-dependent exocytosis of neurotransmitter

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

calcium ion transport from cytosol to endoplasmic reticulum

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

calcium ion import into sarcoplasmic reticulum

determination method

1 reference

14 February 2019

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11507

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000001738

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000001738

ENSRNOP00000024347

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000024347

Sitelinks

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