(Q28560417)

English

Calcium voltage-gated channel subunit alpha1 D

mammalian protein found in Rattus norvegicus

RBD
calcium channel, L type, alpha-1 polypeptide
voltage-gated calcium channel subunit alpha Cav1.3
voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker
voltage-dependent L-type calcium channel subunit alpha-1D
calcium channel alpha-1 subunit
brain class D
Cacna1d
voltage-dependent calcium channel subunit alpha1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
CaV1.3alpha1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Voltage-dependent calcium channel, L-type, alpha-1D subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27732

Voltage-dependent channel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27732

voltage-gated ion channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Voltage-gated calcium channel subunit alpha, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Voltage-dependent calcium channel, alpha-1 subunit, IQ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Voltage-dependent L-type calcium channel, IQ-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ion channel activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

voltage-gated ion channel activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

voltage-gated calcium channel activity

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

14 February 2019

Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

calcium channel activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

protein binding

determination method

1 reference

14 February 2019

Direct interaction and functional coupling between voltage-gated CaV1.3 Ca2+ channel and GABAB receptor subunit 2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

PDZ domain binding

determination method

1 reference

14 February 2019

Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

ankyrin binding

determination method

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

determination method

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

[Ca2+]i regulates trafficking of Cav1.3 (alpha1D Ca2+ channel) in insulin-secreting cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

plasma membrane

determination method

1 reference

14 February 2019

Distribution of calcium channel Ca(V)1.3 immunoreactivity in the rat spinal cord and brain stem

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

voltage-gated calcium channel complex

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

2 references

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Distribution of calcium channel Ca(V)1.3 immunoreactivity in the rat spinal cord and brain stem

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

dendrite membrane

determination method

1 reference

14 February 2019

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

neuronal cell body

determination method

1 reference

14 February 2019

Distribution of calcium channel Ca(V)1.3 immunoreactivity in the rat spinal cord and brain stem

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

biological process

determination method

2 references

calcium ion transport

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

heart development

determination method

1 reference

14 February 2019

Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Regionally selective alterations in expression of the alpha(1D) subunit (Ca(v)1.3) of L-type calcium channels in the hippocampus of aged rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

determination method

1 reference

14 February 2019

Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

calcium-mediated signaling

determination method

1 reference

14 February 2019

Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

response to estradiol

determination method

1 reference

14 February 2019

[Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats].

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

positive regulation of CREB transcription factor activity

determination method

1 reference

14 February 2019

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

regulation of ion transmembrane transport

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

positive regulation of insulin secretion involved in cellular response to glucose stimulus

determination method

1 reference

14 February 2019

The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

positive regulation of adenylate cyclase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

regulation of calcium ion transport

determination method

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

transmembrane transport

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

calcium ion transmembrane transport

determination method

2 references

membrane depolarization during cardiac muscle cell action potential

determination method

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

cellular response to amyloid-beta

determination method

1 reference

14 February 2019

Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

determination method

1 reference

14 February 2019

Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27732

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000041766

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000041766

ENSRNOP00000042492

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000042492

ENSRNOP00000043046

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000043046

ENSRNOP00000051407

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000051407

ENSRNOP00000084179

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000084179

Transporter Classification Database ID

2 references

Transporter Classification database

6 September 2019

Transporter Classification database

29 April 2020

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Multilingual sites(0 entries)

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