(Q28560429)

http://www.ebi.ac.uk/interpro/protein/P14842

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

G-protein alpha-subunit binding

1 reference

14 February 2019

An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

neurotransmitter receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

protein-containing complex binding

1 reference

14 February 2019

Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

integral component of membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

Subcellular distribution of 5-hydroxytryptamine2A and N-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

glutamatergic synapse

EXP

integral component of postsynaptic membrane

2 references

1 reference

14 February 2019

Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

integral component of presynaptic membrane

1 reference

14 February 2019

Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation

biological process

temperature homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

cellular calcium ion homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

G protein-coupled receptor signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

14 February 2019

An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

activation of phospholipase C activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

phospholipase C-activating serotonin receptor signaling pathway

1 reference

14 February 2019

Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

serotonin receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

chemical synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of cell population proliferation

1 reference

14 February 2019

Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of phosphatidylinositol biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

regulation of dopamine secretion

1 reference

14 February 2019

Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

artery smooth muscle contraction

1 reference

14 February 2019

The fenfluramine metabolite (+)-norfenfluramine is vasoactive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

urinary bladder smooth muscle contraction

1 reference

14 February 2019

Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

sensory perception of pain

1 reference

14 February 2019

Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

1 reference

14 February 2019

Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

negative regulation of potassium ion transport

1 reference

14 February 2019

Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of MAP kinase activity

1 reference

14 February 2019

Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

protein localization to cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of fat cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of glycolytic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of vasoconstriction

1 reference

14 February 2019

Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

behavioral response to cocaine

1 reference

14 February 2019

Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

detection of temperature stimulus involved in sensory perception of pain

1 reference

14 February 2019

Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

detection of mechanical stimulus involved in sensory perception of pain

1 reference

14 February 2019

Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

negative regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14842

regulation of synaptic vesicle exocytosis

2 references

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0