(Q28561435)

http://www.ebi.ac.uk/interpro/protein/Q62737

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

electron transfer activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

superoxide-generating NAD(P)H oxidase activity

3 references

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

IBA

oxidoreductase activity

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing

apical plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

NADPH oxidase complex

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

perinuclear endoplasmic reticulum

1 reference

14 February 2019

Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of endothelial cell proliferation

1 reference

14 February 2019

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

negative regulation of glomerular filtration by angiotensin

1 reference

14 February 2019

p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

superoxide metabolic process

4 references

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

1 reference

14 February 2019

Effect of danzhi jiangtang capsule combined exercise on the protein expression of NADPH oxidase p22phox in pancreatic tissues of diabetic rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

smooth muscle hypertrophy

1 reference

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cytochrome complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

electron transport chain

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of cell growth

1 reference

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

response to nutrient levels

1 reference

14 February 2019

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of interleukin-6 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of superoxide anion generation

1 reference

14 February 2019

p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of NAD(P)H oxidase activity

1 reference

14 February 2019

Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of toll-like receptor 2 signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

superoxide anion generation

3 references

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

IBA

innate immune response

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of blood pressure

1 reference

14 February 2019

RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

hydrogen peroxide biosynthetic process

1 reference

14 February 2019

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of phagocytosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

regulation of release of sequestered calcium ion into cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of mucus secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

response to interleukin-1

1 reference

14 February 2019

Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to amino acid stimulus

1 reference

14 February 2019

Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to mechanical stimulus

1 reference

14 February 2019

Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to organic substance

1 reference

14 February 2019

Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to tumor necrosis factor

1 reference

14 February 2019

Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to organic cyclic compound

1 reference

14 February 2019

Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to gamma radiation

1 reference

14 February 2019

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of defense response to bacterium

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

positive regulation of reactive oxygen species biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone

response to aldosterone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to angiotensin

1 reference

14 February 2019

Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737

cellular response to L-glutamine

1 reference

14 February 2019

Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62737