(Q28561767)

Hint domain superfamily

1 reference

hedgehog protein

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Hint domain N-terminal domain, protein family

1 reference

Hint domain C-terminal domain, protein family

1 reference

Hedgehog protein, Hint domain, protein family

1 reference

Hedgehog, N-terminal signalling domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

8 April 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

14 February 2019

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

14 February 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

High frequency stimulation induces sonic hedgehog release from hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

8 April 2019

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

8 April 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

branching involved in blood vessel morphogenesis

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

metanephros development

1 reference

8 April 2019

branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

cell fate specification

1 reference

14 February 2019

neural crest cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

neural tube formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of neuroblast proliferation

1 reference

8 April 2019

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

lymphoid progenitor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

2 references

smoothened signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

pattern specification process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

neuroblast proliferation

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

central nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

digestive tract mesoderm development

1 reference

8 April 2019

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

androgen metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

polarity specification of anterior/posterior axis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

dorsal/ventral pattern formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

response to organonitrogen compound

1 reference

8 April 2019

Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

intein-mediated protein splicing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

spinal cord dorsal/ventral patterning

IEA

1 reference

8 April 2019

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

ventral spinal cord interneuron specification

1 reference

8 April 2019

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

cerebellar granule cell precursor proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

telencephalon regionalization

1 reference

8 April 2019

Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

zona limitans intrathalamica formation

1 reference

8 April 2019

The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

regulation of proteolysis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

male genitalia development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

regulation of epithelial cell differentiation

1 reference

8 April 2019

Sonic hedgehog regulates prostatic growth and epithelial differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

forebrain development

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

hindbrain development

1 reference

8 April 2019

Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

response to retinoic acid

1 reference

8 April 2019

Retinoic acid is essential for Shh/Hoxd signaling during rat limb outgrowth but not for limb initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of neurotrophin production

1 reference

8 April 2019

Sonic Hedgehog regulates brain-derived neurotrophic factor in normal and regenerating cavernous nerves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of immature T cell proliferation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

embryonic digit morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of apoptotic process

1 reference

8 April 2019

Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive thymic T cell selection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative thymic T cell selection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of neuron differentiation

1 reference

8 April 2019

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of smoothened signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of photoreceptor cell differentiation

1 reference

8 April 2019

Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of alpha-beta T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

neuron fate commitment

1 reference

8 April 2019

The upregulated expression of sonic hedgehog in motor neurons after rat facial nerve axotomy

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

branching morphogenesis of an epithelial tube

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

male genitalia morphogenesis

1 reference

8 April 2019

Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

stem cell development

1 reference

8 April 2019

positive regulation of penile erection

1 reference

8 April 2019

Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

epithelial tube branching involved in lung morphogenesis

1 reference

8 April 2019

Spatial expression of Sonic hedgehog in the lung epithelium during branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

fungiform papilla development

1 reference

8 April 2019

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

fungiform papilla morphogenesis

1 reference

8 April 2019

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

fungiform papilla formation

1 reference

8 April 2019

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of oligodendrocyte progenitor proliferation

1 reference

8 April 2019

Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

commissural neuron axon guidance

1 reference

8 April 2019

Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

metanephric mesenchymal cell proliferation involved in metanephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

1 reference

8 April 2019

Significance of sonic hedgehog signaling after massive hepatectomy in a rat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of neuron death

1 reference

8 April 2019

Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of ureter smooth muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of ureter smooth muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

negative regulation of kidney smooth muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of kidney smooth muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of mesenchymal cell proliferation involved in ureter development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

regulation of gene expression

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

oligodendrocyte differentiation

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63673

IBA

has part(s)

Hint domain N-terminal

1 reference

Hedgehog, N-terminal signalling domain

1 reference

Hint domain C-terminal

1 reference

Intein N-terminal splicing region

1 reference

Hedgehog protein, Hint domain

1 reference