(Q28561933)

English

Hydroxysteroid 11-beta dehydrogenase 1

mammalian protein found in Rattus norvegicus

7-oxosteroid reductase
11beta-HSD1
11-beta-hydroxysteroid dehydrogenase, type 1
cortocosteroid 11-beta dehydrogenase
11-beta-hydroxysteroid dehydrogenase 1
Hsd11b1
11-DH
hydroxysteroid dehydrogenase, 11 beta type 1
corticosteroid 11-beta-dehydrogenase isozyme 1
11-beta-HSD1

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Statements

1 reference

25 May 2022

NAD(P)-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16232

Short-chain dehydrogenase/reductase SDR

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16232

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Short-chain dehydrogenase/reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity

3 references

1 January 2018

Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16232&geneProductId=UniProtKB:P16232

1 January 2018

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16232&geneProductId=UniProtKB:P16232

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16232&geneProductId=UniProtKB:P16232

determination method

IBA

oxidoreductase activity

2 references

1 reference

14 February 2019

11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

1 reference

14 February 2019

Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

endoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEA

endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEA

rough endoplasmic reticulum

1 reference

14 February 2019

Light and electron microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEA

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

1 reference

14 February 2019

Light and electron microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

intracellular membrane-bounded organelle

1 reference

14 February 2019

Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

1 reference

14 February 2019

Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEA

glucocorticoid biosynthetic process

1 reference

14 February 2019

Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

glucocorticoid catabolic process

1 reference

14 February 2019

Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

steroid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEA

response to nutrient levels

1 reference

14 February 2019

Maternal low protein diet restricted to the preimplantation period induces a gender-specific change on hepatic gene expression in rat fetuses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEP

regulation of pentose-phosphate shunt

1 reference

14 February 2019

Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IDA

cellular response to estradiol stimulus

1 reference

14 February 2019

17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16232

determination method

IEP

has part(s)

Short-chain dehydrogenase/reductase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16232

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

(Q28561933)

Hydroxysteroid 11-beta dehydrogenase 1

Statements

Identifiers

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