(Q28562064)

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

hydroxymethylglutaryl-CoA reductase (NADPH) activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

IBA

oxidoreductase activity

1 reference

14 February 2019

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

protein homodimerization activity

1 reference

14 February 2019

Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

protein phosphatase 2A binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

cell component

endoplasmic reticulum

endoplasmic reticulum membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

integral component of membrane

intracellular membrane-bounded organelle

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

steroid biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

cholesterol biosynthetic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

ubiquinone metabolic process

IDA

1 reference

14 February 2019

Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

1 reference

14 February 2019

A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

steroid metabolic process

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

cholesterol metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of cell population proliferation

isoprenoid biosynthetic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

farnesyl diphosphate biosynthetic process, mevalonate pathway

1 reference

14 February 2019

Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of striated muscle cell apoptotic process

TAS

1 reference

14 February 2019

Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

coenzyme A metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of stress-activated MAPK cascade

1 reference

14 February 2019

Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of protein catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of apoptotic process

1 reference

14 February 2019

Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of MAP kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation

myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

1 reference

14 February 2019

Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of skeletal muscle tissue development

IEP

1 reference

14 February 2019

3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of protein secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

protein tetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of wound healing

1 reference

14 February 2019

Simvastatin improves wound strength after intestinal anastomosis in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

14 February 2019

The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

negative regulation of amyloid-beta clearance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639

has part(s)

Sterol-sensing domain

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

1 reference