(Q28563071)

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

peptide receptor activity

1 reference

14 February 2019

The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

transmembrane signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

G protein-coupled receptor activity

3 references

14 February 2019

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

glucagon receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

G protein-coupled peptide receptor activity

3 references

14 February 2019

The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

glucagon-like peptide 1 receptor activity

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

14 February 2019

Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

integral component of plasma membrane

1 reference

14 February 2019

The cytoplasmic domain close to the transmembrane region of the glucagon-like peptide-1 receptor contains sequence elements that regulate agonist-dependent internalisation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

2 references

integral component of membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

cell surface receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

2 references

1 reference

14 February 2019

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of cell population proliferation

1 reference

14 February 2019

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells

cAMP-mediated signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Effect of GIP and GLP-1 antagonists on insulin release in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of insulin secretion

1 reference

14 February 2019

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

negative regulation of apoptotic process

1 reference

14 February 2019

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of cell differentiation

1 reference

14 February 2019

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of heart contraction

1 reference

14 February 2019

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

positive regulation of glucose import

1 reference

14 February 2019

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

1 reference

14 February 2019

Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

regulation of calcium ion transport

1 reference

14 February 2019

Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

cellular response to glucagon stimulus

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32301

GPCR, family 2, secretin-like, conserved site

has part(s)

1 reference

GPCR, family 2, extracellular hormone receptor domain

1 reference

GPCR, family 2-like

1 reference