(Q28563113)

http://www.ebi.ac.uk/interpro/protein/P11715

InterPro Release 71.0

reference URL

cytochrome P450, E-class, group I

1 reference

http://www.ebi.ac.uk/interpro/protein/P11715

InterPro Release 71.0

reference URL

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

monooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

steroid 17-alpha-monooxygenase activity

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

14 February 2019

Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

IBA

iron ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

lyase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

heme binding

ISS

2 references

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

cell component

endoplasmic reticulum

1 reference

14 February 2019

Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

cell projection

1 reference

14 February 2019

Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

neuronal cell body

1 reference

14 February 2019

Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

intracellular membrane-bounded organelle

1 reference

14 February 2019

Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

organic acid metabolic process

biological process

1 reference

14 February 2019

Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

steroid biosynthetic process

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

14 February 2019

Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

14 February 2019

androgen biosynthetic process

1 reference

14 February 2019

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

1 reference

14 February 2019

ISS

male gonad development

1 reference

14 February 2019

Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to herbicide

1 reference

14 February 2019

Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to toxic substance

1 reference

14 February 2019

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to organic substance

1 reference

14 February 2019

Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to acetate

1 reference

14 February 2019

Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to ionizing radiation

1 reference

14 February 2019

Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to organic cyclic compound

1 reference

14 February 2019

Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to insecticide

1 reference

14 February 2019

Testicular toxicity of profenofos in matured male rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

biphenyl metabolic process

1 reference

14 February 2019

Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

dibenzo-p-dioxin metabolic process

1 reference

14 February 2019

Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

phenol-containing compound metabolic process

1 reference

14 February 2019

Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

phthalate metabolic process

1 reference

14 February 2019

Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

hippocampus development

1 reference

14 February 2019

Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

adrenal gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

Adrenarche in the rat

ovulation

1 reference

14 February 2019

Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to retinoic acid

1 reference

14 February 2019

Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

Leydig cell differentiation

1 reference

14 February 2019

Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to cytokine

1 reference

14 February 2019

Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to gonadotropin

1 reference

14 February 2019

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to steroid hormone

1 reference

14 February 2019

The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to cAMP

1 reference

14 February 2019

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to methylmercury

1 reference

14 February 2019

An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

response to fungicide

2 references

14 February 2019

Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

14 February 2019

Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

cellular response to lipopolysaccharide

1 reference

14 February 2019

Lipopolysaccharide directly stimulates aldosterone production via toll‐like receptor 2 and toll‐like receptor 4 related PI3K/Akt pathway in rat adrenal zona glomerulosa cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

cellular response to antibiotic

1 reference

14 February 2019

Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

cellular response to gonadotropin stimulus

1 reference

14 February 2019

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

positive regulation of steroid hormone biosynthetic process

IMP

1 reference

14 February 2019

Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715

cytochrome P450, conserved site

IMP

has part(s)

1 reference