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(Q29520083)
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Protein tyrosine phosphatase, non-receptor type 22
mammalian protein found in Rattus norvegicus
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Ptpn22
tyrosine-protein phosphatase non-receptor type 22
protein tyrosine phosphatase, non-receptor type 8
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D4A2D5
part of
Protein-tyrosine phosphatase-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D4A2D5
Tyrosine specific protein phosphatases domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
PTP type protein phosphatase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein-tyrosine phosphatase, catalytic domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein-tyrosine phosphatase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
brown rat
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D4A2D5
encoded by
Ptpn22
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D4A2D5
molecular function
phosphoprotein phosphatase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D4A2D5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
protein tyrosine phosphatase activity
determination method
IEA
ISS
3 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D4A2D5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D4A2D5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
phosphatase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
SH3 domain binding
determination method
IEA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
kinase binding
determination method
IEA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
protein tyrosine kinase binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IPI
cell component
nucleus
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
cytoplasm
determination method
IDA
IEA
ISS
3 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
retrieved
14 February 2019
stated in
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IDA
cytoplasmic side of plasma membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
perinuclear region of cytoplasm
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
biological process
positive regulation of defense response to virus by host
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
regulation of leukocyte migration
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
protein dephosphorylation
determination method
IEA
ISS
3 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of gene expression
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
negative regulation of gene expression
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
dephosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
T cell differentiation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
negative regulation of tumor necrosis factor production
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
regulation of natural killer cell proliferation
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
positive regulation of toll-like receptor 3 signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of toll-like receptor 4 signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of toll-like receptor 7 signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of toll-like receptor 9 signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
peptidyl-tyrosine dephosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
phosphoanandamide dephosphorylation
determination method
IEA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of protein import into nucleus
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
regulation of peptidyl-tyrosine phosphorylation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IMP
T cell receptor signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
negative regulation of T cell activation
determination method
IEA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of ERK1 and ERK2 cascade
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
cellular response to muramyl dipeptide
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of granzyme B production
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
regulation of NIK/NF-kappaB signaling
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of protein K63-linked ubiquitination
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
regulation of calcium ion transmembrane transport
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IMP
negative regulation of p38MAPK cascade
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
positive regulation of CD8-positive, alpha-beta T cell proliferation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D4A2D5
determination method
IEA
has part(s)
Protein-tyrosine phosphatase, catalytic
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D4A2D5
PTP type protein phosphatase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D4A2D5
Tyrosine specific protein phosphatases domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D4A2D5
Protein-tyrosine phosphatase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D4A2D5
Identifiers
RefSeq protein ID
NP_001099930
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
295338
XP_038958000
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
295338
XP_038958001
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
295338
UniProt protein ID
D4A2D5
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D4A2D5
Ensembl protein ID
ENSRNOP00000026556
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000026556
ENSRNOP00000087016
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000087016
Sitelinks
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(0 entries)
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Wikiquote
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Wikisource
(0 entries)
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Wikiversity
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Wikivoyage
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Wiktionary
(0 entries)
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Multilingual sites
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