(Q29530706)

English

Serine peptidase inhibitor, Kazal type 5

mammalian protein found in Mus musculus

Spink5
Netherton syndrome
serine protease inhibitor, Kazal type 5
serine protease inhibitor Kazal-type 5

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Statements

1 reference

25 May 2022

Kazal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q148R4

Kazal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

peptidase inhibitor activity

1 reference

14 February 2019

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

2 references

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

14 February 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

2 references

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

14 February 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

2 references

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

14 February 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method

IEA

biological process

negative regulation of antibacterial peptide production

1 reference

14 February 2019

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method

IMP

regulation of cell adhesion

1 reference

14 February 2019

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method

IMP

negative regulation of proteolysis

1 reference

14 February 2019

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method

IMP

negative regulation of serine-type endopeptidase activity

1 reference

14 February 2019

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method

IMP

negative regulation of serine-type peptidase activity

1 reference

14 February 2019

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q148R4

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

(Q29530706)

Serine peptidase inhibitor, Kazal type 5

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Identifiers

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