(Q29532672)

http://www.ebi.ac.uk/interpro/protein/D3Z4R4

Homeobox domain, protein family

1 reference

basic helix-loop-helix transcription factor

1 reference

Helix-turn-helix motif, protein family

1 reference

Homeobox domain, metazoa, protein family

1 reference

Homeobox, conserved site, protein family

1 reference

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

7 November 2018

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

DNA-binding transcription repressor activity, RNA polymerase II-specific

2 references

5 June 2018

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

14 February 2019

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

DNA-binding transcription factor activity

1 reference

7 November 2018

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

RNA polymerase II cis-regulatory region sequence-specific DNA binding

2 references

14 February 2019

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

DNA-binding transcription factor activity

sequence-specific DNA binding

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

7 November 2018

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

7 November 2018

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

negative regulation of transcription by RNA polymerase II

biological process

1 reference

14 February 2019

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

negative regulation of cell fate commitment

IEA

1 reference

14 February 2019

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

positive regulation of cell fate commitment

1 reference

14 February 2019

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

central nervous system myelination

1 reference

14 February 2019

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

1 reference

7 November 2018

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z4R4&geneProductId=UniProtKB:D3Z4R4

endocrine pancreas development

1 reference

14 February 2019

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

negative regulation of glial cell differentiation

1 reference

14 February 2019

Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

positive regulation of glial cell differentiation

1 reference

14 February 2019

Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

oligodendrocyte differentiation

1 reference

14 February 2019

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

neuromuscular process controlling balance

1 reference

14 February 2019

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

regulation of myelination

1 reference

14 February 2019

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z4R4