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(Q29791796)
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CYtoKinesis defect CELE_K08E3.6
Protein found in Caenorhabditis elegans
CYtoKinesis defect
cyk-4
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9XUS9
part of
Rho GTPase activation protein
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9XUS9
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Rho GTPase-activating protein domain family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Caenorhabditis elegans
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9XUS9
encoded by
cyk-4
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9XUS9
molecular function
GTPase activator activity
determination method
IDA
2 references
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
retrieved
1 January 2018
stated in
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
protein binding
determination method
IPI
3 references
retrieved
1 January 2018
stated in
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IPI
retrieved
1 January 2018
stated in
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IPI
retrieved
1 January 2018
stated in
CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IPI
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9XUS9&geneProductId=UniProtKB:Q9XUS9
determination method
IBA
plasma membrane
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
spindle midzone
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
centralspindlin complex
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
mitotic spindle midzone
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
biological process
mitotic cytokinesis
determination method
IMP
2 references
retrieved
1 January 2018
stated in
The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
signal transduction
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IEA
polar body extrusion after meiotic divisions
determination method
IMP
2 references
retrieved
1 January 2018
stated in
The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
positive regulation of GTPase activity
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IDA
mitotic spindle midzone assembly
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
mitotic cleavage furrow ingression
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
mitotic sister chromatid segregation
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis.
GOA
curator
UniProt
UniProt protein ID
Q9XUS9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9XUS9
determination method
IMP
has part(s)
Rho GTPase-activating protein domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9XUS9
protein kinase C-like, phorbol ester/diacylglycerol-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9XUS9
Identifiers
RefSeq protein ID
NP_499845
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
176815
UniProt protein ID
Q9XUS9
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9XUS9
Ensembl protein ID
K08E3.6.1
1 reference
stated in
ensembl Release 106
Ensembl protein ID
K08E3.6.1
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