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Presenilin sel-12 CELE_F35H12.3
protein found in Caenorhabditis elegans
sel-12
Presenilin sel-12
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P52166
part of
Peptidase A22A, presenilin, nematode type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P52166
found in taxon
Caenorhabditis elegans
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P52166
encoded by
sel-12
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P52166
molecular function
endopeptidase activity
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
aspartic-type endopeptidase activity
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
protein binding
determination method
IPI
2 references
retrieved
1 January 2018
stated in
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IPI
retrieved
1 January 2018
stated in
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IPI
cell component
Golgi membrane
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
nucleus
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
mitochondrial inner membrane
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
lysosomal membrane
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
endoplasmic reticulum
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
endoplasmic reticulum membrane
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
Golgi apparatus
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
integral component of plasma membrane
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
cell cortex
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
cell surface
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
membrane
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
integral component of membrane
determination method
IEA
2 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
Z disc
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
axon
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
growth cone
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
neuromuscular junction
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
ciliary rootlet
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
neuronal cell body
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
dendritic shaft
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
membrane raft
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
perinuclear region of cytoplasm
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IDA
gamma-secretase complex
determination method
ISS
1 reference
retrieved
1 January 2018
stated in
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
ISS
apical plasma membrane
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
perinuclear region of cytoplasm
determination method
IBA
IDA
2 references
retrieved
1 January 2018
stated in
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
biological process
cell fate specification
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IMP
membrane protein ectodomain proteolysis
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
calcium ion transport
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
Notch signaling pathway
determination method
IEA
NAS
2 references
retrieved
1 January 2018
stated in
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
NAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
Notch receptor processing
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
nervous system development
determination method
IEA
IMP
2 references
retrieved
1 January 2018
stated in
Presenilin is required for proper morphology and function of neurons in C. elegans.
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
detection of temperature stimulus
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
Presenilin is required for proper morphology and function of neurons in C. elegans.
GOA
curator
UniProt
UniProt protein ID
P52166
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IMP
protein processing
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
regulation of transforming growth factor beta receptor signaling pathway
determination method
IGI
1 reference
retrieved
1 January 2018
stated in
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IGI
oviposition
determination method
IEA
IMP
2 references
retrieved
1 January 2018
stated in
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IEA
amyloid precursor protein catabolic process
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
negative regulation of apoptotic process
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P52166&geneProductId=UniProtKB:P52166
determination method
IBA
apical protein localization
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IDA
positive regulation of Notch signaling pathway
determination method
IGI
1 reference
retrieved
1 January 2018
stated in
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IGI
post-embryonic animal organ morphogenesis
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IMP
amyloid-beta metabolic process
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52166
determination method
IBA
Identifiers
RefSeq protein ID
NP_508175
1 reference
stated in
NCBI Gene
retrieved
14 December 2018
Entrez Gene ID
180441
UniProt protein ID
P52166
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P52166
Ensembl protein ID
F35H12.3
1 reference
stated in
ensembl Release 96
Ensembl protein ID
F35H12.3
Sitelinks
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Wikibooks
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Wikinews
(0 entries)
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Wikiquote
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Wikisource
(0 entries)
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Wikiversity
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Wikivoyage
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Multilingual sites
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