(Q29809694)

English

Yorkie Dmel_CG4005

Protein found in Drosophila melanogaster

CG4005-PG
CG4005 gene product from transcript CG4005-RG
yki
CG4005-PF
yki-PD
yki-PH
CG4005-PD
yorkie
yki-PF
yorki
yki-PG
CG4005-PH

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q45VV3

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transcription coactivator activity

determination method

5 references

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

protein binding

determination method

7 references

10 September 2018

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

In vivo regulation of Yorkie phosphorylation and localization.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

transcription factor binding

determination method

2 references

14-3-3 protein binding

determination method

1 reference

10 September 2018

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

4 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

1 reference

10 September 2018

The Hippo signaling pathway interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

1 reference

10 September 2018

The Hippo signaling pathway interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

cytoplasmic vesicle

determination method

1 reference

10 September 2018

The Hippo signaling pathway interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

determination method

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

biological process

cell fate specification

determination method

1 reference

10 September 2018

Opposite feedbacks in the Hippo pathway for growth control and neural fate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

morphogenesis of an epithelial sheet

determination method

1 reference

10 September 2018

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

heart morphogenesis

determination method

1 reference

10 September 2018

Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

regulation of transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

border follicle cell migration

determination method

1 reference

10 September 2018

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

cell population proliferation

determination method

4 references

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

cell competition in a multicellular organism

determination method

1 reference

10 September 2018

dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

hippo signaling

determination method

1 reference

1 January 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

regulation of growth

determination method

1 reference

10 September 2018

The bantam microRNA is a target of the hippo tumor-suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

negative regulation of apoptotic process

determination method

3 references

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of growth

determination method

1 reference

10 September 2018

Cooperative regulation of growth by Yorkie and Mad through bantam

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

histone H3-K4 methylation

determination method

1 reference

1 January 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of glial cell proliferation

determination method

1 reference

10 September 2018

Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

stem cell proliferation

determination method

1 reference

10 September 2018

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of histone H3-K4 trimethylation

determination method

1 reference

10 September 2018

Yorkie promotes transcription by recruiting a histone methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

hippo signaling

determination method

4 references

10 September 2018

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

10 September 2018

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of histone H3-K4 methylation

determination method

1 reference

10 September 2018

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

positive regulation of imaginal disc growth

determination method

1 reference

10 September 2018

Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q45VV3&geneProductId=UniProtKB:Q45VV3

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q45VV3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Multilingual sites(0 entries)

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