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(Q29809717)
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SAPK-interacting protein 1 Dmel_CG10105
Protein found in Drosophila melanogaster
Sin1-PA
CG10105 gene product from transcript CG10105-RA
stress-activated map kinase-interacting protein 1
Stress-activated protein kinase [SAPK]-interacting protein
Sin1
SAPK-interacting protein 1
CG10105-PA
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9V719
part of
SAPK-interacting protein 1, Pleckstrin-homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Sin1, N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Sin1, middle CRIM domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9V719
encoded by
Sin1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9V719
molecular function
molecular function
determination method
ND
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9V719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
ND
phosphatidylinositol-4,5-bisphosphate binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
protein kinase binding
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
ISS
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
plasma membrane
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
TORC2 complex
determination method
IBA
IEA
IGI
3 references
retrieved
27 March 2018
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V719&geneProductId=UniProtKB:Q9V719
determination method
IGI
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V719&geneProductId=UniProtKB:Q9V719
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V719&geneProductId=UniProtKB:Q9V719
determination method
IBA
TORC2 complex
determination method
IBA
IGI
2 references
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IGI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
biological process
regulation of protein phosphorylation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9V719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IEA
establishment or maintenance of actin cytoskeleton polarity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
stress-activated protein kinase signaling cascade
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V719&geneProductId=UniProtKB:Q9V719
determination method
IBA
stress granule assembly
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
dendrite morphogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
positive regulation of protein phosphorylation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
cellular response to insulin stimulus
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
TORC2 signaling
determination method
IBA
IGI
2 references
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IGI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IBA
positive regulation of synaptic assembly at neuromuscular junction
determination method
IGI
IMP
2 references
retrieved
8 April 2019
stated in
Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
retrieved
8 April 2019
stated in
Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IGI
positive regulation of insulin receptor signaling pathway
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
positive regulation of protein kinase B signaling
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
retrieved
8 April 2019
stated in
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
positive regulation of protein serine/threonine kinase activity
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V719
determination method
IMP
has part(s)
Sin1, N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9V719
Sin1, middle CRIM domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9V719
SAPK-interacting protein 1, Pleckstrin-homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9V719
Identifiers
RefSeq protein ID
NP_610963
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
36604
UniProt protein ID
Q9V719
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9V719
Ensembl protein ID
FBpp0086616
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0086616
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