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Vav guanine nucleotide exchange factor Dmel_CG7893
Protein found in Drosophila melanogaster
Vav-PC
CG7893-PD
Vav ortholog
Vav-PD
Vav-PB
Vav-PA
Vav
CG7893-PC
CG7893-PB
CG7893 gene product from transcript CG7893-RB
Vav guanine nucleotide exchange factor
CG7893-PA
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NHV9
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
CH domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Vav, PH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Calponin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Vav, SH2 domain, invertebrate, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NHV9
encoded by
Vav
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NHV9
molecular function
guanyl-nucleotide exchange factor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NHV9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IEA
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NHV9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IEA
cell component
cellular component
determination method
ND
1 reference
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NHV9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NHV9&geneProductId=UniProtKB:Q9NHV9
determination method
ND
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NHV9&geneProductId=UniProtKB:Q9NHV9
determination method
IEA
cytosol
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
biological process
compound eye morphogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
dorsal closure
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
axonogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The guanine exchange factor vav controls axon growth and guidance during Drosophila development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
axon guidance
determination method
IMP
2 references
retrieved
8 April 2019
stated in
The guanine exchange factor vav controls axon growth and guidance during Drosophila development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
central nervous system development
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
The guanine exchange factor vav controls axon growth and guidance during Drosophila development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IGI
open tracheal system development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
myoblast fusion
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
cell migration
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
actin cytoskeleton reorganization
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
melanotic encapsulation of foreign target
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IEA
negative regulation of epidermal growth factor receptor signaling pathway
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
photoreceptor cell axon guidance
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The guanine exchange factor vav controls axon growth and guidance during Drosophila development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
activation of GTPase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
regulation of adherens junction organization
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
epidermal growth factor receptor signaling pathway
determination method
IDA
IGI
2 references
retrieved
8 April 2019
stated in
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IGI
retrieved
8 April 2019
stated in
DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
border follicle cell migration
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
vascular endothelial growth factor receptor signaling pathway
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IDA
positive regulation of ERK1 and ERK2 cascade
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
positive regulation of actin cytoskeleton reorganization
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NHV9
determination method
IMP
has part(s)
Vav, SH2 domain, invertebrate
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
protein kinase C-like, phorbol ester/diacylglycerol-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
Calponin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
Vav, PH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NHV9
Identifiers
RefSeq protein ID
NP_001097030
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32920
NP_001259703
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32920
NP_573372
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32920
NP_728235
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32920
UniProt protein ID
Q9NHV9
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NHV9
Ensembl protein ID
FBpp0074448
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0074448
FBpp0112228
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0112228
FBpp0305901
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0305901
FBpp0074449
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0074449
Sitelinks
Wikipedia
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Wikibooks
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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