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(Q29811803)
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Necrotic Dmel_CG1857
Protein found in Drosophila melanogaster
CG1857 gene product from transcript CG1857-RA
necrotic
CG1857-PA
serine protease inhibitor 3
nec
nec-PA
serpin43Ac
necrotic serpin
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7JWX3
part of
Serpin superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7JWX3
serpin family
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7JWX3
Serpin, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serpin domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7JWX3
encoded by
nec
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7JWX3
molecular function
serine-type endopeptidase inhibitor activity
determination method
IDA
NAS
3 references
retrieved
27 March 2018
stated in
The immune response of Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
NAS
retrieved
27 March 2018
stated in
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
27 March 2018
stated in
Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
serine-type endopeptidase inhibitor activity
determination method
IBA
IDA
NAS
4 references
retrieved
10 September 2018
stated in
The immune response of Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
NAS
retrieved
10 September 2018
stated in
Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
10 September 2018
stated in
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IBA
serine-type endopeptidase inhibitor activity
determination method
IBA
IDA
3 references
retrieved
8 April 2019
stated in
Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
8 April 2019
stated in
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IBA
cell component
extracellular space
determination method
IDA
IEA
3 references
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IEA
retrieved
27 March 2018
stated in
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
27 March 2018
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
extracellular space
determination method
IBA
IDA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IEA
retrieved
8 April 2019
stated in
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
8 April 2019
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IBA
biological process
immune response
determination method
IEP
1 reference
retrieved
10 September 2018
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IEP
Toll signaling pathway
determination method
TAS
2 references
retrieved
10 September 2018
stated in
What can Drosophila tell us about serpins, thrombosis and dementia?
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
TAS
retrieved
10 September 2018
stated in
The evolution and genetics of innate immunity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
TAS
response to fungus
determination method
IEP
1 reference
retrieved
1 January 2018
stated in
Peptidomic and proteomic analyses of the systemic immune response of Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IEP
negative regulation of endopeptidase activity
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IEA
antifungal humoral response
determination method
IGI
TAS
2 references
retrieved
10 September 2018
stated in
The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
TAS
retrieved
10 September 2018
stated in
The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IGI
regulation of proteolysis
determination method
IDA
IMP
2 references
retrieved
10 September 2018
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IMP
retrieved
10 September 2018
stated in
Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IDA
negative regulation of Toll signaling pathway
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IMP
response to bacterium
determination method
IEP
1 reference
retrieved
1 January 2018
stated in
Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IEP
negative regulation of endopeptidase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IBA
antifungal humoral response
determination method
IGI
1 reference
retrieved
1 January 2018
stated in
The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7JWX3&geneProductId=UniProtKB:Q7JWX3
determination method
IGI
negative regulation of innate immune response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IMP
negative regulation of proteolysis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IMP
negative regulation of serine-type endopeptidase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IDA
response to fungus
determination method
HEP
1 reference
retrieved
8 April 2019
stated in
Peptidomic and proteomic analyses of the systemic immune response of Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
HEP
negative regulation of Toll signaling pathway
determination method
IGI
IMP
3 references
retrieved
8 April 2019
stated in
The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IMP
retrieved
8 April 2019
stated in
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IMP
retrieved
8 April 2019
stated in
Activation of Drosophila Toll during fungal infection by a blood serine protease
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7JWX3
determination method
IGI
has part(s)
Serpin, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7JWX3
Serpin domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7JWX3
Identifiers
RefSeq protein ID
NP_524851
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
45908
UniProt protein ID
Q7JWX3
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7JWX3
Ensembl protein ID
FBpp0088123
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0088123
Sitelinks
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