(Q29812214)

English

Nicastrin Dmel_CG7012

Protein found in Drosophila melanogaster

CG7012-PC
CG7012-PD
dNicastrin
nicastrin
agoraphobic
Nct-PA
CG7012-PE
CG7012-PA
Nct-PE
CG7012 gene product from transcript CG7012-RC
Nct-PC
Nct
Nct-PD

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Statements

1 reference

25 May 2022

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9VC27

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

endopeptidase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

1 January 2018

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IDA

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

determination method

IDA

gamma-secretase complex

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

8 April 2019

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

determination method

HDA

biological process

membrane protein ectodomain proteolysis

1 reference

14 January 2019

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IMP

cytoskeleton organization

1 reference

14 January 2019

Drosophila nicastrin is essential for the intramembranous cleavage of notch

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IMP

Notch signaling pathway

4 references

14 January 2019

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

14 January 2019

Drosophila nicastrin is essential for the intramembranous cleavage of notch

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

14 January 2019

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IEA

photoreceptor cell morphogenesis

1 reference

14 January 2019

Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IMP

regulation of compound eye photoreceptor development

1 reference

8 April 2019

Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

1 reference

14 January 2019

Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VC27&geneProductId=UniProtKB:Q9VC27

determination method

IMP

Notch receptor processing

5 references

8 April 2019

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Drosophila nicastrin is essential for the intramembranous cleavage of notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

determination method

IBA

Notch signaling pathway

8 references

8 April 2019

Epsin-Dependent Ligand Endocytosis Activates Notch by Force.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Drosophila nicastrin is essential for the intramembranous cleavage of notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

determination method

IEA

Notch receptor processing, ligand-dependent

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VC27

determination method

IGI

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

(Q29812214)

Nicastrin Dmel_CG7012

Statements

Identifiers

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