(Q29812380)

English

Expanded Dmel_CG4114

Protein found in Drosophila melanogaster

ex-PA
CG4114-PB
expanded
ex
CG4114-PA
braille
CG4114 gene product from transcript CG4114-RA
ex-PB

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07436

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07436

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07436

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM central domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM, C-terminal PH-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

SH3 domain binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

transcription factor binding

determination method

1 reference

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

determination method

1 reference

8 April 2019

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

plasma membrane

determination method

2 references

zonula adherens

determination method

1 reference

8 April 2019

Membrane targeting.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

apical plasma membrane

determination method

3 references

1 January 2018

Control of growth and organ size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

Kibra-Ex-Mer complex

determination method

1 reference

1 January 2018

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

apical plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

cytoplasmic side of apical plasma membrane

determination method

4 references

8 April 2019

Kibra is a regulator of the Salvador/Warts/Hippo signaling network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

biological process

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of exit from mitosis

determination method

1 reference

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

border follicle cell migration

determination method

1 reference

8 April 2019

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

negative regulation of cell population proliferation

determination method

5 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

regulation of signal transduction

determination method

1 reference

8 April 2019

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

ovarian follicle cell development

determination method

1 reference

8 April 2019

A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

endocytic recycling

determination method

1 reference

8 April 2019

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

hippo signaling

determination method

4 references

1 January 2018

Vamana Couples Fat Signaling to the Hippo Pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of hippo signaling

determination method

1 reference

1 January 2018

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

negative regulation of hippo signaling

determination method

positive regulation of phosphorylation

determination method

1 reference

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of apoptotic process

determination method

1 reference

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

negative regulation of imaginal disc growth

determination method

4 references

1 January 2018

Control of growth and organ size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

Zyxin links fat signaling to the hippo pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of cell differentiation

determination method

1 reference

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

regulation of organ growth

determination method

1 reference

1 January 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

determination method

negative regulation of organ growth

determination method

3 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

positive regulation of hippo signaling

determination method

12 references

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The WW domain protein Kibra acts upstream of Hippo in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

regulation of growth

determination method

1 reference

8 April 2019

Genes affecting cell competition in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

negative regulation of imaginal disc growth

determination method

3 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

Zyxin links fat signaling to the hippo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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