(Q29812472)

English

Spastin Dmel_CG5977

Protein found in Drosophila melanogaster

CG5977-PE
spas-PC
spas-PB
D-spastin
CG5977 gene product from transcript CG5977-RD
spasin
CG5977-PF
spas-PA
CG5977-PA
spas-PE
Dm-Spastin
dspastin
spas
CG5977-PC
CG5977-PB
spas-PF
CG5977-PD
spas-PD
spastin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8I0P1

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8I0P1

ATPase, AAA-type, core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MIT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

ATPase, AAA-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

protein binding

determination method

1 reference

8 April 2019

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

2 references

microtubule binding

determination method

1 reference

1 January 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

microtubule-severing ATPase activity

determination method

4 references

16 July 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

16 July 2018

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

hydrolase activity

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

ATPase activity

determination method

1 reference

16 July 2018

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

alpha-tubulin binding

determination method

1 reference

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

microtubule-severing ATPase activity

determination method

5 references

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

isomerase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

synaptic vesicle

determination method

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

microtubule cytoskeleton

determination method

1 reference

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

neuromuscular junction

determination method

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

terminal bouton

determination method

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

biological process

mitotic sister chromatid segregation

determination method

1 reference

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

microtubule cytoskeleton organization

determination method

3 references

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

nervous system development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

locomotory behavior

determination method

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

transmission of nerve impulse

determination method

1 reference

8 April 2019

The centrosome in human genetic disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of microtubule depolymerization

determination method

4 references

1 January 2018

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

1 January 2018

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

1 January 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

1 January 2018

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method

hemocyte migration

determination method

1 reference

8 April 2019

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of lipid metabolic process

determination method

1 reference

8 April 2019

Spastin binds to lipid droplets and affects lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

negative regulation of synaptic assembly at neuromuscular junction

determination method

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of synaptic assembly at neuromuscular junction

determination method

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

regulation of synaptic plasticity

determination method

1 reference

8 April 2019

The centrosome in human genetic disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of axon extension involved in regeneration

determination method

1 reference

8 April 2019

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of dendrite morphogenesis

determination method

1 reference

8 April 2019

Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

negative regulation of neuromuscular synaptic transmission

determination method

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of neuromuscular synaptic transmission

determination method

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

regulation of terminal button organization

determination method

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

mitotic spindle elongation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

mitotic chromosome movement towards spindle pole

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

adult locomotory behavior

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

positive regulation of microtubule depolymerization

determination method

5 references

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

protein hexamerization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

regulation of synapse structure or activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

microtubule severing

determination method

3 references

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

cytoplasmic microtubule organization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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