(Q29813039)

http://www.ebi.ac.uk/interpro/protein/P22812

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tube, Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

protein serine/threonine kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

6 references

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

A heterotrimeric death domain complex in Toll signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Three-dimensional structure of a complex between the death domains of Pelle and Tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

protein domain specific binding

IPI

1 reference

8 April 2019

Three-dimensional structure of a complex between the death domains of Pelle and Tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

protein tyrosine kinase binding

IPI

1 reference

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

3 references

27 March 2018

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

27 March 2018

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

27 March 2018

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

27 March 2018

Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

4 references

10 September 2018

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

IDA

biological process

protein phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

1 reference

8 April 2019

Three-dimensional structure of a complex between the death domains of Pelle and Tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

1 reference

10 September 2018

The antimicrobial host defense of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

larval somatic muscle development

IEA

1 reference

8 April 2019

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

Three-dimensional structure of a complex between the death domains of Pelle and Tube

IMP

Toll signaling pathway

7 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

A universal role for MyD88 in TLR/IL-1R-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

Drosophila: the genetics of innate immune recognition and response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

The immune response of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

10 September 2018

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

1 reference

8 April 2019

Fly immunity: great expectations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

antifungal humoral response

1 reference

10 September 2018

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis

IMP

hemocyte proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

intracellular signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

Three-dimensional structure of a complex between the death domains of Pelle and Tube

innate immune response

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

determination of dorsal/ventral asymmetry

2 references

8 April 2019

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

1 reference

10 September 2018

The antimicrobial host defense of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22812&geneProductId=UniProtKB:P22812

cytokine-mediated signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

Three-dimensional structure of a complex between the death domains of Pelle and Tube

Toll signaling pathway

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

A heterotrimeric death domain complex in Toll signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

8 April 2019

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22812

dorsal/ventral pattern formation

IGI

2 references

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22812

Death domain

1 reference

stated in

InterPro Release 71.0