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Inositol-requiring enzyme-1 Dmel_CG4583
Protein found in Drosophila melanogaster
Ire
ire-1
Inositol-requiring enzyme-1
inositol required 1
Ire1-PB
CG4583 gene product from transcript CG4583-RB
CG4583-PB
Ire1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
A8JR46
part of
Quinoprotein alcohol dehydrogenase-like superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
Serine/threonine-protein kinase/endoribonuclease IRE2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
KEN domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
KEN domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
PUB domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Pyrrolo-quinoline quinone beta-propeller repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
A8JR46
encoded by
Ire1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
A8JR46
molecular function
endoribonuclease activity
determination method
IDA
IMP
3 references
retrieved
21 June 2018
stated in
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
21 June 2018
stated in
Unfolded protein response in a Drosophila model for retinal degeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
21 June 2018
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IDA
ribonuclease activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
protein kinase activity
determination method
IEA
NAS
2 references
retrieved
21 June 2018
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
NAS
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IEA
ATP binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
endoribonuclease activity
determination method
IBA
IDA
IMP
4 references
retrieved
8 April 2019
stated in
Unfolded protein response in a Drosophila model for retinal degeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
8 April 2019
stated in
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
8 April 2019
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
protein kinase activity
determination method
IBA
IEA
NAS
3 references
retrieved
8 April 2019
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
protein serine/threonine kinase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
unfolded protein binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
cell component
endoplasmic reticulum membrane
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
IRE1-TRAF2-ASK1 complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
biological process
compound eye photoreceptor cell differentiation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
compound eye photoreceptor fate commitment
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
mRNA processing
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
mRNA catabolic process
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
protein phosphorylation
determination method
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
Golgi organization
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
endoplasmic reticulum unfolded protein response
determination method
IDA
IMP
2 references
retrieved
1 January 2018
stated in
Unfolded protein response in a Drosophila model for retinal degeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
1 January 2018
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IDA
response to endoplasmic reticulum stress
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IDA
regulation of RNA splicing
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IDA
rhabdomere morphogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
RNA phosphodiester bond hydrolysis, endonucleolytic
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
endoplasmic reticulum unfolded protein response
determination method
IDA
1 reference
retrieved
21 June 2018
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IDA
IRE1-mediated unfolded protein response
determination method
IMP
1 reference
retrieved
21 June 2018
stated in
Unfolded protein response in a Drosophila model for retinal degeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=A8JR46&geneProductId=UniProtKB:A8JR46
determination method
IMP
RNA phosphodiester bond hydrolysis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IEA
endoplasmic reticulum unfolded protein response
determination method
IBA
IDA
2 references
retrieved
8 April 2019
stated in
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
IRE1-mediated unfolded protein response
determination method
IBA
IMP
2 references
retrieved
8 April 2019
stated in
Unfolded protein response in a Drosophila model for retinal degeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IMP
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A8JR46
determination method
IBA
has part(s)
PUB domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
Pyrrolo-quinoline quinone beta-propeller repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
KEN domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A8JR46
Identifiers
RefSeq protein ID
NP_001097839
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
42358
UniProt protein ID
A8JR46
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
A8JR46
Ensembl protein ID
FBpp0112160
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0112160
Sitelinks
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Wikiquote
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